Actin cytoskeleton in dendritic spine development and plasticity

Actin cytoskeleton in dendritic spine development and plasticity

Highlights • Dendritic spines depend on the actin cytoskeleton and its remodeling for their structure and plasticity. • Actin nucleation factors enable the formation and growth of distinct F-actin networks in spines. • Capping of actin filaments is a crucial step for the actin networks underlying sp...

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Veröffentlicht in:Current opinion in neurobiology 2016-08, Vol.39, p.86-92
Hauptverfasser: Lei, Wenliang, Omotade, Omotola F, Myers, Kenneth R, Zheng, James Q
Format: Artikel
Sprache:eng
Schlagworte:
Actin Cytoskeleton - metabolism
Dendritic Spines - physiology
Humans
Neurogenesis - physiology
Neurology
Neuronal Plasticity - physiology
Psychiatry
Synapses
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container_title Current opinion in neurobiology
container_volume 39
creator Lei, Wenliang
Omotade, Omotola F
Myers, Kenneth R
Zheng, James Q
description Highlights • Dendritic spines depend on the actin cytoskeleton and its remodeling for their structure and plasticity. • Actin nucleation factors enable the formation and growth of distinct F-actin networks in spines. • Capping of actin filaments is a crucial step for the actin networks underlying spine formation and plasticity. • Different actin regulatory proteins are spatiotemporally targeted and regulated in spines. • Disruption of the actin cytoskeleton underlies synaptic dysfunction in brain disorders.
doi_str_mv 10.1016/j.conb.2016.04.010
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subjects Actin Cytoskeleton - metabolism
Dendritic Spines - physiology
Humans
Neurogenesis - physiology
Neurology
Neuronal Plasticity - physiology
Psychiatry
Synapses
title Actin cytoskeleton in dendritic spine development and plasticity
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