The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts

We recently reported the association of the PCSK6 gene with handedness through a quantitative genome-wide association study (GWAS; P < 0.5 × 10(-8)) for a relative hand skill measure in individuals with dyslexia. PCSK6 activates Nodal, a morphogen involved in regulating left-right body axis deter...

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Veröffentlicht in:	Human molecular genetics 2016-05, Vol.25 (9), p.1771-1779
Hauptverfasser:	Shore, Robert, Covill, Laura, Pettigrew, Kerry A, Brandler, William M, Diaz, Rebeca, Xu, Yiwang, Tello, Javier A, Talcott, Joel B, Newbury, Dianne F, Stein, John, Monaco, Anthony P, Paracchini, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Functional Laterality - genetics Gene Expression Regulation Genetic Variation - genetics Genome-Wide Association Study Humans Introns - genetics Minisatellite Repeats - genetics Nodal Protein - genetics Promoter Regions, Genetic - genetics Proprotein Convertases - genetics RNA, Long Noncoding - genetics Serine Endopeptidases - genetics
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