Small cell neuroendocrine carcinoma of tracheostomy site in a patient with a history of juvenile laryngeal papillomatosis
Juvenile laryngeal papillomatosis is the commonest cause of benign epithelial tumours of the larynx. Following diagnostic biopsy, surgical debulking is the mainstay of therapy. The condition is often recurrent with further papillomas forming after debridement, requiring serial procedures and occasio...
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| Veröffentlicht in: | BMJ case reports 2016-08, Vol.2016, p.bcr2016216370 |
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| creator | Violet Wilmot, Victoria Nixon, Iain James Nixon, Ioanna Fragkandrea |
| description | Juvenile laryngeal papillomatosis is the commonest cause of benign epithelial tumours of the larynx. Following diagnostic biopsy, surgical debulking is the mainstay of therapy. The condition is often recurrent with further papillomas forming after debridement, requiring serial procedures and occasionally demanding tracheostomy. Rarely, the disease can undergo malignant transformation; most commonly to squamous cell carcinoma. We describe the first reported case of small cell neuroendocrine carcinoma occurring in the previous tracheostomy site of a 29-year-old male with a history of juvenile laryngeal papillomatosis. The patient, with a background of multiple treatments for juvenile papillomas, presented with voice change, breathing difficultly and erythema at the site of previous tracheostomy. Induction chemotherapy followed by chemoradiation was used to treat the lesion with a good response to initial therapy. |
| doi_str_mv | 10.1136/bcr-2016-216370 |
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Following diagnostic biopsy, surgical debulking is the mainstay of therapy. The condition is often recurrent with further papillomas forming after debridement, requiring serial procedures and occasionally demanding tracheostomy. Rarely, the disease can undergo malignant transformation; most commonly to squamous cell carcinoma. We describe the first reported case of small cell neuroendocrine carcinoma occurring in the previous tracheostomy site of a 29-year-old male with a history of juvenile laryngeal papillomatosis. The patient, with a background of multiple treatments for juvenile papillomas, presented with voice change, breathing difficultly and erythema at the site of previous tracheostomy. Induction chemotherapy followed by chemoradiation was used to treat the lesion with a good response to initial therapy.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2016-216370</identifier><identifier>PMID: 27507691</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adult ; Airway management ; Biopsy ; Cancer therapies ; Carcinoma, Neuroendocrine - diagnostic imaging ; Carcinoma, Small Cell - diagnostic imaging ; Chemotherapy ; Dyspnea - etiology ; Family medical history ; Human papillomavirus ; Humans ; Infections ; Laryngeal Neoplasms - diagnostic imaging ; Laryngeal Neoplasms - surgery ; Larynx ; Lung cancer ; Male ; Medical prognosis ; Metastasis ; Neoplasm Recurrence, Local - diagnostic imaging ; Neoplasms, Second Primary - diagnostic imaging ; Ostomy ; Papilloma - diagnostic imaging ; Papilloma - surgery ; Postoperative Complications - diagnostic imaging ; Radiation therapy ; Rare Disease ; Throat ; Tomography, X-Ray Computed ; Tracheostomy ; United Kingdom ; Voice Disorders - etiology ; White</subject><ispartof>BMJ case reports, 2016-08, Vol.2016, p.bcr2016216370</ispartof><rights>2016 BMJ Publishing Group Ltd</rights><rights>2016 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2016 2016 BMJ Publishing Group Ltd</rights><rights>2016 BMJ Publishing Group Ltd 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3710-fcab79a4b3b1f521dafdcdb8ac394024adb4cd28751494da3697e458cab347f43</citedby><cites>FETCH-LOGICAL-b3710-fcab79a4b3b1f521dafdcdb8ac394024adb4cd28751494da3697e458cab347f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986009/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986009/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27507691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Violet Wilmot, Victoria</creatorcontrib><creatorcontrib>Nixon, Iain James</creatorcontrib><creatorcontrib>Nixon, Ioanna Fragkandrea</creatorcontrib><title>Small cell neuroendocrine carcinoma of tracheostomy site in a patient with a history of juvenile laryngeal papillomatosis</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>Juvenile laryngeal papillomatosis is the commonest cause of benign epithelial tumours of the larynx. Following diagnostic biopsy, surgical debulking is the mainstay of therapy. The condition is often recurrent with further papillomas forming after debridement, requiring serial procedures and occasionally demanding tracheostomy. Rarely, the disease can undergo malignant transformation; most commonly to squamous cell carcinoma. We describe the first reported case of small cell neuroendocrine carcinoma occurring in the previous tracheostomy site of a 29-year-old male with a history of juvenile laryngeal papillomatosis. The patient, with a background of multiple treatments for juvenile papillomas, presented with voice change, breathing difficultly and erythema at the site of previous tracheostomy. Induction chemotherapy followed by chemoradiation was used to treat the lesion with a good response to initial therapy.</description><subject>Adult</subject><subject>Airway management</subject><subject>Biopsy</subject><subject>Cancer therapies</subject><subject>Carcinoma, Neuroendocrine - diagnostic imaging</subject><subject>Carcinoma, Small Cell - diagnostic imaging</subject><subject>Chemotherapy</subject><subject>Dyspnea - etiology</subject><subject>Family medical history</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Infections</subject><subject>Laryngeal Neoplasms - diagnostic imaging</subject><subject>Laryngeal Neoplasms - surgery</subject><subject>Larynx</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Neoplasm Recurrence, Local - diagnostic imaging</subject><subject>Neoplasms, Second Primary - diagnostic imaging</subject><subject>Ostomy</subject><subject>Papilloma - diagnostic imaging</subject><subject>Papilloma - surgery</subject><subject>Postoperative Complications - diagnostic imaging</subject><subject>Radiation therapy</subject><subject>Rare Disease</subject><subject>Throat</subject><subject>Tomography, X-Ray Computed</subject><subject>Tracheostomy</subject><subject>United Kingdom</subject><subject>Voice Disorders - etiology</subject><subject>White</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc9LHDEUx4NUdFHPvUnASxGmJpPMZOYiiNgfsOBBC72Fl0xmN0smWZMZZf_7ZrtbsV7MIXkhn--X9_JF6DMlXyll9ZXSsSgJrYuS1kyQAzSjohKFaMnvT2_qY3SW0orkxShvODtCx6WoiKhbOkObhwGcw9rkzZspBuO7oKP1BmuI2vowAA49HiPopQlpDMMGJzsabD0GvIbRGj_iFzsu83VpMxA3W8FqejbeOoMdxI1fGHAZXlvnsuEYkk2n6LAHl8zZ_jxBv77dPd7-KOb333_e3swLxQQlRa9BiRa4Yor2VUk76DvdqQY0azkpOXSK665sREV5yztgdSsMr5osY1z0nJ2g653velKD6XRuN4KT62iH3JkMYOX_L94u5SI8S942NSFtNviyN4jhaTJplINN2w8Db8KUJG0oaQQhTZ3Ri3foKkzR5_H-UoKRmrNMXe0oHUNK0fSvzVAit8nKnKzcJit3yWbF-dsZXvl_OWbgcgeoYfWh2x-yMa-b</recordid><startdate>20160809</startdate><enddate>20160809</enddate><creator>Violet Wilmot, Victoria</creator><creator>Nixon, Iain James</creator><creator>Nixon, Ioanna Fragkandrea</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160809</creationdate><title>Small cell neuroendocrine carcinoma of tracheostomy site in a patient with a history of juvenile laryngeal papillomatosis</title><author>Violet Wilmot, Victoria ; 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Following diagnostic biopsy, surgical debulking is the mainstay of therapy. The condition is often recurrent with further papillomas forming after debridement, requiring serial procedures and occasionally demanding tracheostomy. Rarely, the disease can undergo malignant transformation; most commonly to squamous cell carcinoma. We describe the first reported case of small cell neuroendocrine carcinoma occurring in the previous tracheostomy site of a 29-year-old male with a history of juvenile laryngeal papillomatosis. The patient, with a background of multiple treatments for juvenile papillomas, presented with voice change, breathing difficultly and erythema at the site of previous tracheostomy. Induction chemotherapy followed by chemoradiation was used to treat the lesion with a good response to initial therapy.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>27507691</pmid><doi>10.1136/bcr-2016-216370</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Airway management Biopsy Cancer therapies Carcinoma, Neuroendocrine - diagnostic imaging Carcinoma, Small Cell - diagnostic imaging Chemotherapy Dyspnea - etiology Family medical history Human papillomavirus Humans Infections Laryngeal Neoplasms - diagnostic imaging Laryngeal Neoplasms - surgery Larynx Lung cancer Male Medical prognosis Metastasis Neoplasm Recurrence, Local - diagnostic imaging Neoplasms, Second Primary - diagnostic imaging Ostomy Papilloma - diagnostic imaging Papilloma - surgery Postoperative Complications - diagnostic imaging Radiation therapy Rare Disease Throat Tomography, X-Ray Computed Tracheostomy United Kingdom Voice Disorders - etiology White |
| title | Small cell neuroendocrine carcinoma of tracheostomy site in a patient with a history of juvenile laryngeal papillomatosis |
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