Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival

Type 2 Diabetes (T2DM) affects more than 300 million people worldwide. One of the hallmarks of T2DM is peripheral insulin resistance, in part due to unproductive insulin signaling through the insulin receptor. The insulin receptor ( INSR ) exists as two isoforms, INSR-A and INSR-B, which results fro...

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Veröffentlicht in:	Scientific reports 2016-08, Vol.6 (1), p.31222-31222, Article 31222
Hauptverfasser:	Malakar, Pushkar, Chartarifsky, Lital, Hija, Ayat, Leibowitz, Gil, Glaser, Benjamin, Dor, Yuval, Karni, Rotem
Format:	Artikel
Sprache:	eng
Schlagworte:	13 38 38/1 38/77 631/337/1645/1792 692/163 96 96/2 96/95 Alternative Splicing Animals Antigens, CD - biosynthesis Antigens, CD - genetics Antisense oligonucleotides Apoptosis Beta cells Cell death Cell Line, Tumor Cell Survival Diabetes mellitus Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Humanities and Social Sciences Humans Insulin Insulin - genetics Insulin - metabolism Insulin resistance Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Isoforms MAP kinase MAP Kinase Signaling System Mice multidisciplinary Pancreas Receptor, Insulin - biosynthesis Receptor, Insulin - genetics Relative abundance Rodents Science Signal transduction Splicing factors
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