A quantitative study of the size of benign and malignant lymphoid follicles
The mean areas of lymphoid follicles have been determined in 20 specimens of malignant follicular (centrocytic-centroblastic) lymphoma, 15 specimens of reactive follicular hyperplasia and 10 palatine tonsils. In all of the benign specimens and whenever possible for those showing malignancy, the area...
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| Veröffentlicht in: | Journal of clinical pathology 1983-09, Vol.36 (9), p.1055-1061 |
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| container_title | Journal of clinical pathology |
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| creator | Crocker, J Jones, E L Curran, R C |
| description | The mean areas of lymphoid follicles have been determined in 20 specimens of malignant follicular (centrocytic-centroblastic) lymphoma, 15 specimens of reactive follicular hyperplasia and 10 palatine tonsils. In all of the benign specimens and whenever possible for those showing malignancy, the areas of both the whole follicles (including the "mantle" zones) and of the follicle centres were measured; this procedure was facilitated by means of the Reichert-Jung (Kontron) MOP-AMO3 image-analyser. Reactive lymph nodes were found to have larger mean follicle areas than centrocytic-centroblastic lymphomas; the areas of reactive follicles also show greater variation than do those of their malignant counterparts. In addition, the "mantle" zone is usually absent from malignant follicles but may account for up to 65.5% of the mean total follicle size in reactive lymph nodes and tonsils. |
| doi_str_mv | 10.1136/jcp.36.9.1055 |
| format | Article |
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In all of the benign specimens and whenever possible for those showing malignancy, the areas of both the whole follicles (including the "mantle" zones) and of the follicle centres were measured; this procedure was facilitated by means of the Reichert-Jung (Kontron) MOP-AMO3 image-analyser. Reactive lymph nodes were found to have larger mean follicle areas than centrocytic-centroblastic lymphomas; the areas of reactive follicles also show greater variation than do those of their malignant counterparts. In addition, the "mantle" zone is usually absent from malignant follicles but may account for up to 65.5% of the mean total follicle size in reactive lymph nodes and tonsils.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.36.9.1055</identifier><identifier>PMID: 6350370</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Child ; Diagnosis, Differential ; Female ; Hematologic and hematopoietic diseases ; Humans ; Hyperplasia - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymph Nodes - pathology ; Lymphoma, Follicular - pathology ; Male ; Medical sciences ; Middle Aged ; Palatine Tonsil - pathology</subject><ispartof>Journal of clinical pathology, 1983-09, Vol.36 (9), p.1055-1061</ispartof><rights>1984 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Sep 1983</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b575t-c32f70bb84aa8096990705a992cfcfdc49e585d1c5e381dbca8a048f41c6b8073</citedby><cites>FETCH-LOGICAL-b575t-c32f70bb84aa8096990705a992cfcfdc49e585d1c5e381dbca8a048f41c6b8073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC498469/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC498469/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9461509$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6350370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crocker, J</creatorcontrib><creatorcontrib>Jones, E L</creatorcontrib><creatorcontrib>Curran, R C</creatorcontrib><title>A quantitative study of the size of benign and malignant lymphoid follicles</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>The mean areas of lymphoid follicles have been determined in 20 specimens of malignant follicular (centrocytic-centroblastic) lymphoma, 15 specimens of reactive follicular hyperplasia and 10 palatine tonsils. In all of the benign specimens and whenever possible for those showing malignancy, the areas of both the whole follicles (including the "mantle" zones) and of the follicle centres were measured; this procedure was facilitated by means of the Reichert-Jung (Kontron) MOP-AMO3 image-analyser. Reactive lymph nodes were found to have larger mean follicle areas than centrocytic-centroblastic lymphomas; the areas of reactive follicles also show greater variation than do those of their malignant counterparts. In addition, the "mantle" zone is usually absent from malignant follicles but may account for up to 65.5% of the mean total follicle size in reactive lymph nodes and tonsils.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Hyperplasia - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphoma, Follicular - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Palatine Tonsil - pathology</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtvEzEUhS0EKqGwZIk0EgixmXA9fi9YtFF5iAoUqXTBxvJ4PI2Dx5OOZ6qGX4-jROGxwZt7rfOd62sdhJ5jmGNM-Nu13cwJn6s5BsYeoBmmoioppvwhmgFUuFSC8sfoSUprAEwEJifohBMGRMAMfT4rbicTRz-a0d-5Io1Tsy36thhX-eJ_ul1fu-hvYmFiU3Qm5DYbirDtNqveN0Xbh-BtcOkpetSakNyzQz1F395fXC0-lpdfP3xanF2WNRNsLC2pWgF1LakxEhRXCgQwo1RlW9s2lirHJGuwZY5I3NTWSANUthRbXksQ5BS928_dTHXnGuviOJigN4PvzLDVvfH6byX6lb7p7zRVknKV_a8P_qG_nVwadeeTdSGY6PopaQm8kgJDBl_-A677aYj5bxoLAbQS-WSq3FN26FMaXHvcBIPeRaRzRDoXpXcRZf7Fn-sf6UMmWX910E2yJrSDidanI6YoxwzU72d9Gt39UTbDD80FEUx_uV7o8-Xy_PuVuNbLzL_Z83W3_s-GvwDwuLZB</recordid><startdate>19830901</startdate><enddate>19830901</enddate><creator>Crocker, J</creator><creator>Jones, E L</creator><creator>Curran, R C</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19830901</creationdate><title>A quantitative study of the size of benign and malignant lymphoid follicles</title><author>Crocker, J ; Jones, E L ; Curran, R C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b575t-c32f70bb84aa8096990705a992cfcfdc49e585d1c5e381dbca8a048f41c6b8073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Hyperplasia - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphoma, Follicular - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Palatine Tonsil - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crocker, J</creatorcontrib><creatorcontrib>Jones, E L</creatorcontrib><creatorcontrib>Curran, R C</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crocker, J</au><au>Jones, E L</au><au>Curran, R C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A quantitative study of the size of benign and malignant lymphoid follicles</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>1983-09-01</date><risdate>1983</risdate><volume>36</volume><issue>9</issue><spage>1055</spage><epage>1061</epage><pages>1055-1061</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>The mean areas of lymphoid follicles have been determined in 20 specimens of malignant follicular (centrocytic-centroblastic) lymphoma, 15 specimens of reactive follicular hyperplasia and 10 palatine tonsils. In all of the benign specimens and whenever possible for those showing malignancy, the areas of both the whole follicles (including the "mantle" zones) and of the follicle centres were measured; this procedure was facilitated by means of the Reichert-Jung (Kontron) MOP-AMO3 image-analyser. Reactive lymph nodes were found to have larger mean follicle areas than centrocytic-centroblastic lymphomas; the areas of reactive follicles also show greater variation than do those of their malignant counterparts. In addition, the "mantle" zone is usually absent from malignant follicles but may account for up to 65.5% of the mean total follicle size in reactive lymph nodes and tonsils.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>6350370</pmid><doi>10.1136/jcp.36.9.1055</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of clinical pathology, 1983-09, Vol.36 (9), p.1055-1061 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Biological and medical sciences Child Diagnosis, Differential Female Hematologic and hematopoietic diseases Humans Hyperplasia - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Lymphoma, Follicular - pathology Male Medical sciences Middle Aged Palatine Tonsil - pathology |
| title | A quantitative study of the size of benign and malignant lymphoid follicles |
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