Pharmacokinetic models of morphine and its metabolites in neonates:: Systematic comparisons of models from the literature, and development of a new meta-model

Morphine is commonly used for pain management in preterm neonates. The aims of this study were to compare published models of neonatal pharmacokinetics of morphine and its metabolites with a new dataset, and to combine the characteristics of the best predictive models to design a meta-model for morp...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2016-09, Vol.92, p.117-130
Hauptverfasser:	Knøsgaard, Katrine Rørbæk, Foster, David John Richard, Kreilgaard, Mads, Sverrisdóttir, Eva, Upton, Richard Neil, van den Anker, Johannes N
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - blood Analgesics, Opioid - pharmacokinetics Analgesics, Opioid - therapeutic use Female Humans Infant, Newborn Infant, Premature Male Models, Biological Morphine - blood Morphine - pharmacokinetics Morphine - therapeutic use Pain - blood Pain - drug therapy
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