A Retrospective Observational Study to Assess Prescription Pattern in Patients with Type B Aortic Dissection and Treatment Outcome
Aortic dissection is a life-threatening condition. However, the use of medication to treat it remains unclear in our population, particularly in patients with a type B aortic dissection (TBAD) who do not receive surgery. This retrospective cohort study evaluated antihypertensive prescription pattern...
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| creator | Kuo, Chen-Chun Huang, Jiann-Woei Wang, Shih-Han Chen, Chung-Yu Liao, Kuang-Ming Huang, Yaw-Bin |
| description | Aortic dissection is a life-threatening condition. However, the use of medication to treat it remains unclear in our population, particularly in patients with a type B aortic dissection (TBAD) who do not receive surgery. This retrospective cohort study evaluated antihypertensive prescription patterns and outcomes in patients with nonsurgical TBAD. We reviewed the hospital records of patients with TBAD at a medical center in Taiwan from January 2008 to June 2013 to assess the baseline information, prescribing pattern, event rate, and clinical effectiveness of different antihypertensive treatment strategies. A Cox proportional hazards model was used to estimate outcomes in different antihypertensive strategies. The primary endpoints were all-cause mortality and hospital admission for an aortic dissection. We included 106 patients with a mean follow-up period of 2.75 years. The most common comorbidity was hypertension followed by dyslipidemia and diabetes mellitus. Study endpoints mostly occurred within 6 months after the index date. Over 80% of patients received dual or triple antihypertensive strategies. Patients treated with different treatment strategies did not have a significantly increased risk of a primary outcome compared with those treated with a monotherapy. We found no significant difference in the primary outcome following the use of different antihypertensive medication regimes. |
| doi_str_mv | 10.1155/2016/5173898 |
| format | Article |
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However, the use of medication to treat it remains unclear in our population, particularly in patients with a type B aortic dissection (TBAD) who do not receive surgery. This retrospective cohort study evaluated antihypertensive prescription patterns and outcomes in patients with nonsurgical TBAD. We reviewed the hospital records of patients with TBAD at a medical center in Taiwan from January 2008 to June 2013 to assess the baseline information, prescribing pattern, event rate, and clinical effectiveness of different antihypertensive treatment strategies. A Cox proportional hazards model was used to estimate outcomes in different antihypertensive strategies. The primary endpoints were all-cause mortality and hospital admission for an aortic dissection. We included 106 patients with a mean follow-up period of 2.75 years. The most common comorbidity was hypertension followed by dyslipidemia and diabetes mellitus. Study endpoints mostly occurred within 6 months after the index date. Over 80% of patients received dual or triple antihypertensive strategies. Patients treated with different treatment strategies did not have a significantly increased risk of a primary outcome compared with those treated with a monotherapy. We found no significant difference in the primary outcome following the use of different antihypertensive medication regimes.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2016/5173898</identifier><identifier>PMID: 27563668</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aged ; Aneurysms ; Antihypertensive Agents - administration & dosage ; Antihypertensive drugs ; Antilipemic agents ; Aortic Aneurysm, Thoracic - complications ; Aortic Aneurysm, Thoracic - drug therapy ; Aortic Aneurysm, Thoracic - mortality ; Aortic Aneurysm, Thoracic - pathology ; Biomedical research ; Care and treatment ; Comorbidity ; Diabetes Mellitus - mortality ; Diabetes Mellitus - pathology ; Dissecting aneurysm ; Dyslipidemias - mortality ; Dyslipidemias - pathology ; Female ; Hospital Records ; Hospitalization ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - drug therapy ; Hypertension - mortality ; Hypertension - pathology ; Male ; Medical centers ; Medical records ; Medical research ; Medicine, Experimental ; Middle Aged ; Mortality ; Patient outcomes ; Practice Patterns, Physicians ; Retrospective Studies ; Studies ; Surgery ; Taiwan ; Treatment Outcome</subject><ispartof>BioMed research international, 2016-01, Vol.2016 (2016), p.1-10</ispartof><rights>Copyright © 2016 Kuang-Ming Liao et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Kuang-Ming Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Kuang-Ming Liao et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-aa2fe4a813b2a2d24fbdc836a5dfbe9814cf25244f32d58d33169d998afec9a3</citedby><cites>FETCH-LOGICAL-c532t-aa2fe4a813b2a2d24fbdc836a5dfbe9814cf25244f32d58d33169d998afec9a3</cites><orcidid>0000-0002-6024-0108 ; 0000-0001-7206-3957 ; 0000-0001-5464-5056 ; 0000-0003-4364-8248</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983657/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983657/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27563668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ioannou, Christos V.</contributor><creatorcontrib>Kuo, Chen-Chun</creatorcontrib><creatorcontrib>Huang, Jiann-Woei</creatorcontrib><creatorcontrib>Wang, Shih-Han</creatorcontrib><creatorcontrib>Chen, Chung-Yu</creatorcontrib><creatorcontrib>Liao, Kuang-Ming</creatorcontrib><creatorcontrib>Huang, Yaw-Bin</creatorcontrib><title>A Retrospective Observational Study to Assess Prescription Pattern in Patients with Type B Aortic Dissection and Treatment Outcome</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Aortic dissection is a life-threatening condition. However, the use of medication to treat it remains unclear in our population, particularly in patients with a type B aortic dissection (TBAD) who do not receive surgery. This retrospective cohort study evaluated antihypertensive prescription patterns and outcomes in patients with nonsurgical TBAD. We reviewed the hospital records of patients with TBAD at a medical center in Taiwan from January 2008 to June 2013 to assess the baseline information, prescribing pattern, event rate, and clinical effectiveness of different antihypertensive treatment strategies. A Cox proportional hazards model was used to estimate outcomes in different antihypertensive strategies. The primary endpoints were all-cause mortality and hospital admission for an aortic dissection. We included 106 patients with a mean follow-up period of 2.75 years. The most common comorbidity was hypertension followed by dyslipidemia and diabetes mellitus. Study endpoints mostly occurred within 6 months after the index date. Over 80% of patients received dual or triple antihypertensive strategies. Patients treated with different treatment strategies did not have a significantly increased risk of a primary outcome compared with those treated with a monotherapy. We found no significant difference in the primary outcome following the use of different antihypertensive medication regimes.</description><subject>Aged</subject><subject>Aneurysms</subject><subject>Antihypertensive Agents - administration & dosage</subject><subject>Antihypertensive drugs</subject><subject>Antilipemic agents</subject><subject>Aortic Aneurysm, Thoracic - complications</subject><subject>Aortic Aneurysm, Thoracic - drug therapy</subject><subject>Aortic Aneurysm, Thoracic - mortality</subject><subject>Aortic Aneurysm, Thoracic - pathology</subject><subject>Biomedical research</subject><subject>Care and treatment</subject><subject>Comorbidity</subject><subject>Diabetes Mellitus - mortality</subject><subject>Diabetes Mellitus - pathology</subject><subject>Dissecting aneurysm</subject><subject>Dyslipidemias - mortality</subject><subject>Dyslipidemias - pathology</subject><subject>Female</subject><subject>Hospital Records</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - 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However, the use of medication to treat it remains unclear in our population, particularly in patients with a type B aortic dissection (TBAD) who do not receive surgery. This retrospective cohort study evaluated antihypertensive prescription patterns and outcomes in patients with nonsurgical TBAD. We reviewed the hospital records of patients with TBAD at a medical center in Taiwan from January 2008 to June 2013 to assess the baseline information, prescribing pattern, event rate, and clinical effectiveness of different antihypertensive treatment strategies. A Cox proportional hazards model was used to estimate outcomes in different antihypertensive strategies. The primary endpoints were all-cause mortality and hospital admission for an aortic dissection. We included 106 patients with a mean follow-up period of 2.75 years. The most common comorbidity was hypertension followed by dyslipidemia and diabetes mellitus. Study endpoints mostly occurred within 6 months after the index date. 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| subjects | Aged Aneurysms Antihypertensive Agents - administration & dosage Antihypertensive drugs Antilipemic agents Aortic Aneurysm, Thoracic - complications Aortic Aneurysm, Thoracic - drug therapy Aortic Aneurysm, Thoracic - mortality Aortic Aneurysm, Thoracic - pathology Biomedical research Care and treatment Comorbidity Diabetes Mellitus - mortality Diabetes Mellitus - pathology Dissecting aneurysm Dyslipidemias - mortality Dyslipidemias - pathology Female Hospital Records Hospitalization Humans Hypertension Hypertension - complications Hypertension - drug therapy Hypertension - mortality Hypertension - pathology Male Medical centers Medical records Medical research Medicine, Experimental Middle Aged Mortality Patient outcomes Practice Patterns, Physicians Retrospective Studies Studies Surgery Taiwan Treatment Outcome |
| title | A Retrospective Observational Study to Assess Prescription Pattern in Patients with Type B Aortic Dissection and Treatment Outcome |
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