Forkhead box O member FOXO1 regulates the majority of follicle-stimulating hormone responsive genes in ovarian granulosa cells

FSH promotes maturation of ovarian follicles. One pathway activated by FSH in granulosa cells (GCs) is phosphatidylinositol-3 kinase/AKT. The AKT target FOXO1 is reported to function primarily as a repressor of FSH genes, including Ccnd2 and Inha. Based on its broad functions in other tissues, we hy...

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Veröffentlicht in:	Molecular and cellular endocrinology 2016-10, Vol.434, p.116-126
Hauptverfasser:	Herndon, Maria K., Law, Nathan C., Donaubauer, Elyse M., Kyriss, Brandon, Hunzicker-Dunn, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Female Follicle Stimulating Hormone - pharmacology Follicle-stimulating hormone FOXO1 Gene Expression Profiling - methods Gene Expression Regulation - drug effects Gene Regulatory Networks - drug effects Granulosa cells Granulosa Cells - cytology Granulosa Cells - drug effects High-Throughput Nucleotide Sequencing - methods Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Rats RNA deep sequencing Sequence Analysis, RNA - methods
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