Methodologies in creating skin substitutes
The creation of skin substitutes has significantly decreased morbidity and mortality of skin wounds. Although there are still a number of disadvantages of currently available skin substitutes, there has been a significant decline in research advances over the past several years in improving these sk...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2016-09, Vol.73 (18), p.3453-3472 |
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| creator | Nicholas, Mathew N. Jeschke, Marc G. Amini-Nik, Saeid |
| description | The creation of skin substitutes has significantly decreased morbidity and mortality of skin wounds. Although there are still a number of disadvantages of currently available skin substitutes, there has been a significant decline in research advances over the past several years in improving these skin substitutes. Clinically most skin substitutes used are acellular and do not use growth factors to assist wound healing, key areas of potential in this field of research. This article discusses the five necessary attributes of an ideal skin substitute. It comprehensively discusses the three major basic components of currently available skin substitutes: scaffold materials, growth factors, and cells, comparing and contrasting what has been used so far. It then examines a variety of techniques in how to incorporate these basic components together to act as a guide for further research in the field to create cellular skin substitutes with better clinical results. |
| doi_str_mv | 10.1007/s00018-016-2252-8 |
| format | Article |
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Although there are still a number of disadvantages of currently available skin substitutes, there has been a significant decline in research advances over the past several years in improving these skin substitutes. Clinically most skin substitutes used are acellular and do not use growth factors to assist wound healing, key areas of potential in this field of research. This article discusses the five necessary attributes of an ideal skin substitute. It comprehensively discusses the three major basic components of currently available skin substitutes: scaffold materials, growth factors, and cells, comparing and contrasting what has been used so far. It then examines a variety of techniques in how to incorporate these basic components together to act as a guide for further research in the field to create cellular skin substitutes with better clinical results.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-016-2252-8</identifier><identifier>PMID: 27154041</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biochemistry ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biomedical and Life Sciences ; Biomedical materials ; Biomedicine ; Cell Adhesion - drug effects ; Cell Biology ; Fibroblasts - cytology ; Fibroblasts - drug effects ; Fibroblasts - metabolism ; Growth factors ; Humans ; Intercellular Signaling Peptides and Proteins - pharmacology ; Life Sciences ; Mesenchymal Stem Cells - cytology ; Mesenchymal Stem Cells - drug effects ; Mesenchymal Stem Cells - metabolism ; morbidity ; mortality ; Plastic surgery ; Review ; Skin ; skin (animal) ; Skin - anatomy & histology ; Skin - injuries ; Skin - metabolism ; Skin, Artificial - economics ; tissue repair ; Tissue Scaffolds ; Tissues ; Wound healing</subject><ispartof>Cellular and molecular life sciences : CMLS, 2016-09, Vol.73 (18), p.3453-3472</ispartof><rights>Springer International Publishing 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-346a11142053239024041bf423c6efa47cccf027db2d6407026c47023b694ab43</citedby><cites>FETCH-LOGICAL-c536t-346a11142053239024041bf423c6efa47cccf027db2d6407026c47023b694ab43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982839/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982839/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,313,314,723,776,780,788,881,27899,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27154041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nicholas, Mathew N.</creatorcontrib><creatorcontrib>Jeschke, Marc G.</creatorcontrib><creatorcontrib>Amini-Nik, Saeid</creatorcontrib><title>Methodologies in creating skin substitutes</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>The creation of skin substitutes has significantly decreased morbidity and mortality of skin wounds. Although there are still a number of disadvantages of currently available skin substitutes, there has been a significant decline in research advances over the past several years in improving these skin substitutes. Clinically most skin substitutes used are acellular and do not use growth factors to assist wound healing, key areas of potential in this field of research. This article discusses the five necessary attributes of an ideal skin substitute. It comprehensively discusses the three major basic components of currently available skin substitutes: scaffold materials, growth factors, and cells, comparing and contrasting what has been used so far. It then examines a variety of techniques in how to incorporate these basic components together to act as a guide for further research in the field to create cellular skin substitutes with better clinical results.</description><subject>Biochemistry</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical materials</subject><subject>Biomedicine</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Biology</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - drug effects</subject><subject>Fibroblasts - metabolism</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - pharmacology</subject><subject>Life Sciences</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Mesenchymal Stem Cells - drug effects</subject><subject>Mesenchymal Stem Cells - metabolism</subject><subject>morbidity</subject><subject>mortality</subject><subject>Plastic surgery</subject><subject>Review</subject><subject>Skin</subject><subject>skin (animal)</subject><subject>Skin - anatomy & histology</subject><subject>Skin - injuries</subject><subject>Skin - metabolism</subject><subject>Skin, Artificial - economics</subject><subject>tissue repair</subject><subject>Tissue Scaffolds</subject><subject>Tissues</subject><subject>Wound healing</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkV1LHDEUhkOp1M8f0Juy0BspjJ5zkslkbgplsSoo3ih4FzLZzDo6O9FkptB_b8bZLiqU9iJfnCfvSd6Xsc8IRwhQHEcAQJUByowop0x9YDsoCLISCvy43ktFt9tsN8b7BOeK5Ce2TQXmAgTusG-Xrr_zC9_6ZePirOlmNjjTN91yFh_SKQ5V7Jt-6F3cZ1u1aaM7WK977ObnyfX8LLu4Oj2f_7jIbM5ln3EhDeLYOufES6CxUVUL4la62ojCWlsDFYuKFlJAASStSDOvZClMJfge-z7pPg7Vyi2s6_pgWv0YmpUJv7U3jX5b6Zo7vfS_tCgVKV4mgcO1QPBPg4u9XjXRurY1nfND1JRsS0Mo9U8UFeYFggTxPyhSichH1a_v0Hs_hC6Z9kKVyFGOz8SJssHHGFy9-SKCHvPVU7465avHfPWo_OW1N5sbfwJNAE1ATKVu6cKr1n9VfQbOsK08</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Nicholas, Mathew N.</creator><creator>Jeschke, Marc G.</creator><creator>Amini-Nik, Saeid</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20160901</creationdate><title>Methodologies in creating skin substitutes</title><author>Nicholas, Mathew N. ; Jeschke, Marc G. ; Amini-Nik, Saeid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-346a11142053239024041bf423c6efa47cccf027db2d6407026c47023b694ab43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biochemistry</topic><topic>Biocompatible Materials - 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| subjects | Biochemistry Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biomedical and Life Sciences Biomedical materials Biomedicine Cell Adhesion - drug effects Cell Biology Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Growth factors Humans Intercellular Signaling Peptides and Proteins - pharmacology Life Sciences Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism morbidity mortality Plastic surgery Review Skin skin (animal) Skin - anatomy & histology Skin - injuries Skin - metabolism Skin, Artificial - economics tissue repair Tissue Scaffolds Tissues Wound healing |
| title | Methodologies in creating skin substitutes |
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