Induction of apoptosis by HBI‐8000 in adult T‐cell leukemia/lymphoma is associated with activation of Bim and NLRP3

Adult T‐cell leukemia/lymphoma (ATL) is an aggressive T‐cell malignancy caused by human T‐cell lymphotropic virus 1. Treatment options for acute ATL patients include chemotherapy, stem cell transplantation, and recently the anti‐chemokine (C‐C motif) receptor 4 antibody, although most patients still...

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Veröffentlicht in:	Cancer science 2016-08, Vol.107 (8), p.1124-1133
Hauptverfasser:	Hasegawa, Hiroo, Bissonnette, Reid P., Gillings, Mireille, Sasaki, Daisuke, Taniguchi, Hiroaki, Kitanosono, Hideaki, Tsuruda, Kazuto, Kosai, Kousuke, Uno, Naoki, Morinaga, Yoshitomo, Imaizumi, Yoshitaka, Miyazaki, Yasushi, Yanagihara, Katsunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Adult T‐cell leukemia lymphoma Annexin A5 - metabolism Antibodies Apoptosis Apoptosis - drug effects Bcl-2-Like Protein 11 - metabolism Benzamides - pharmacology Bim BIM protein Caspase 3 - metabolism Cell activation Cell culture Cell cycle Cell death Cell Death - drug effects Cell Line, Tumor Cell Survival - drug effects Chemokines Chemotherapy Deoxyribonucleic acid DNA DNA microarrays Gene expression Histone deacetylase histone deacetylase inhibitors Histones - drug effects Histones - metabolism Humans Hypoxia Inflammasomes Inflammasomes - metabolism Leukemia Leukemia-Lymphoma, Adult T-Cell - metabolism Leukemia-Lymphoma, Adult T-Cell - pathology Lymphoma Malignancy Medical prognosis Membrane Potential, Mitochondrial NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Oligonucleotide Array Sequence Analysis Original Patients Protein Array Analysis Protein expression Proteins Pyridines - pharmacology Pyrin protein Retroviridae siRNA Software Stem cell transplantation Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Viral infections
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