Gastric biomarkers: a global review
Gastric cancer is an aggressive disease with a poor 5-year survival and large global burden of disease. The disease is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Despite the many prognostic, predictive, and therapeutic biomarkers invest...
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| Veröffentlicht in: | World journal of surgical oncology 2016-08, Vol.14 (1), p.212, Article 212 |
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| container_title | World journal of surgical oncology |
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| creator | Baniak, Nick Senger, Jenna-Lynn Ahmed, Shahid Kanthan, S C Kanthan, Rani |
| description | Gastric cancer is an aggressive disease with a poor 5-year survival and large global burden of disease. The disease is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Despite the many prognostic, predictive, and therapeutic biomarkers investigated to date, gastric cancer continues to be detected at an advanced stage with resultant poor clinical outcomes.
This is a global review of gastric biomarkers with an emphasis on HER2, E-cadherin, fibroblast growth factor receptor, mammalian target of rapamycin, and hepatocyte growth factor receptor as well as sections on microRNAs, long noncoding RNAs, matrix metalloproteinases, PD-L1, TP53, and microsatellite instability.
A deeper understanding of the pathogenesis and biological features of gastric cancer, including the identification and characterization of diagnostic, prognostic, predictive, and therapeutic biomarkers, hopefully will provide improved clinical outcomes. |
| doi_str_mv | 10.1186/s12957-016-0969-3 |
| format | Article |
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This is a global review of gastric biomarkers with an emphasis on HER2, E-cadherin, fibroblast growth factor receptor, mammalian target of rapamycin, and hepatocyte growth factor receptor as well as sections on microRNAs, long noncoding RNAs, matrix metalloproteinases, PD-L1, TP53, and microsatellite instability.
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A deeper understanding of the pathogenesis and biological features of gastric cancer, including the identification and characterization of diagnostic, prognostic, predictive, and therapeutic biomarkers, hopefully will provide improved clinical outcomes.</description><subject>Animals</subject><subject>Biological markers</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Humans</subject><subject>Review</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - therapy</subject><issn>1477-7819</issn><issn>1477-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkV1LwzAYhYMobk5_gDdSGHjXmTRpPrwQxtApDLzR65CmyRZtm5F0E_-9HdWxgeTiDXmfczjhAHCN4AQhTu8iykTOUohoCgUVKT4BQ0QYSxlH4vTgPgAXMX5AmGGc43MwyFiOCKVsCMZzFdvgdFI4X6vwaUK8T1SyrHyhqiSYrTNfl-DMqiqaq985Au9Pj2-z53TxOn-ZTRepJoK1qRCZYEoVwsAcYkUw4qUoIePacs4N1rmlpbEWslxwrK2wShRaCVhSLqAmeAQeet_1pqhNqU3TBlXJdXBdsm_plZPHm8at5NJvJRE8Ixh3BuPeYKkqI11jfYfp2kUtp4RyjnhOs46a_EN1pzS1074x1nXvR4LbA8HKqKpdRV9tWuebeAyiHtTBxxiM3WdHUO4ak31jsmtM7hqTu8w3h5_eK_4qwj8nF4-R</recordid><startdate>20160811</startdate><enddate>20160811</enddate><creator>Baniak, Nick</creator><creator>Senger, Jenna-Lynn</creator><creator>Ahmed, Shahid</creator><creator>Kanthan, S C</creator><creator>Kanthan, Rani</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20160811</creationdate><title>Gastric biomarkers: a global review</title><author>Baniak, Nick ; Senger, Jenna-Lynn ; Ahmed, Shahid ; Kanthan, S C ; Kanthan, Rani</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-99297aab9e0503a4318d9d078cf888e3c5f6deff075983cf9fa9bca90d6890c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Biological markers</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Humans</topic><topic>Review</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baniak, Nick</creatorcontrib><creatorcontrib>Senger, Jenna-Lynn</creatorcontrib><creatorcontrib>Ahmed, Shahid</creatorcontrib><creatorcontrib>Kanthan, S C</creatorcontrib><creatorcontrib>Kanthan, Rani</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baniak, Nick</au><au>Senger, Jenna-Lynn</au><au>Ahmed, Shahid</au><au>Kanthan, S C</au><au>Kanthan, Rani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric biomarkers: a global review</atitle><jtitle>World journal of surgical oncology</jtitle><addtitle>World J Surg Oncol</addtitle><date>2016-08-11</date><risdate>2016</risdate><volume>14</volume><issue>1</issue><spage>212</spage><pages>212-</pages><artnum>212</artnum><issn>1477-7819</issn><eissn>1477-7819</eissn><abstract>Gastric cancer is an aggressive disease with a poor 5-year survival and large global burden of disease. The disease is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Despite the many prognostic, predictive, and therapeutic biomarkers investigated to date, gastric cancer continues to be detected at an advanced stage with resultant poor clinical outcomes.
This is a global review of gastric biomarkers with an emphasis on HER2, E-cadherin, fibroblast growth factor receptor, mammalian target of rapamycin, and hepatocyte growth factor receptor as well as sections on microRNAs, long noncoding RNAs, matrix metalloproteinases, PD-L1, TP53, and microsatellite instability.
A deeper understanding of the pathogenesis and biological features of gastric cancer, including the identification and characterization of diagnostic, prognostic, predictive, and therapeutic biomarkers, hopefully will provide improved clinical outcomes.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27514667</pmid><doi>10.1186/s12957-016-0969-3</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | World journal of surgical oncology, 2016-08, Vol.14 (1), p.212, Article 212 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Animals Biological markers Biomarkers, Tumor - metabolism Complications and side effects Development and progression Diagnosis Humans Review Stomach cancer Stomach Neoplasms - diagnosis Stomach Neoplasms - metabolism Stomach Neoplasms - therapy |
| title | Gastric biomarkers: a global review |
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