Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease, characterized by antinuclear autoantibodies (ANA) and immunocomplexes, commonly affecting kidneys, skin, heart, lung or even the brain. We have shown that JunBΔep mice develop a SLE phenotype linked to increased epidermal Interleukin (IL)‐...

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Veröffentlicht in:	Experimental dermatology 2016-04, Vol.25 (4), p.305-310
Hauptverfasser:	Birner, Peter, Heider, Susanne, Petzelbauer, Peter, Wolf, Peter, Kornauth, Christoph, Kuroll, Madeleine, Merkel, Olaf, Steiner, Günter, Kishimoto, Tadamitsu, Rose-John, Stefan, Soleiman, Afschin, Moriggl, Richard, Kenner, Lukas
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - analysis Animals Antibodies, Antinuclear - immunology Body Weight Disease Models, Animal Gene Expression Regulation Immunoglobulin G - immunology Immunoglobulins - metabolism interleukin 6 Interleukin-6 Receptor alpha Subunit - antagonists & inhibitors Interleukin-6 Receptor alpha Subunit - metabolism jun B Kidney - metabolism Kidney - physiopathology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Mice Mice, Inbred C57BL Original Phenotype Signal Transduction Skin - metabolism Skin - pathology Skin Diseases - pathology SLE Transcription Factors - genetics
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