Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma

Adoptive cell transfer, the infusion of large numbers of activated autologous lymphocytes, can mediate objective tumor regression in a majority of patients with metastatic melanoma (52 of 93; 56%). Addition and intensification of total body irradiation (TBI) to the preparative lymphodepleting chemot...

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Veröffentlicht in:	Journal of clinical oncology 2016-07, Vol.34 (20), p.2389-2397
Hauptverfasser:	Goff, Stephanie L, Dudley, Mark E, Citrin, Deborah E, Somerville, Robert P, Wunderlich, John R, Danforth, David N, Zlott, Daniel A, Yang, James C, Sherry, Richard M, Kammula, Udai S, Klebanoff, Christopher A, Hughes, Marybeth S, Restifo, Nicholas P, Langhan, Michelle M, Shelton, Thomas E, Lu, Lily, Kwong, Mei Li M, Ilyas, Sadia, Klemen, Nicholas D, Payabyab, Eden C, Morton, Kathleen E, Toomey, Mary Ann, Steinberg, Seth M, White, Donald E, Rosenberg, Steven A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Female Humans Immunotherapy, Adoptive Lymphocyte Depletion Lymphocytes, Tumor-Infiltrating - immunology Male Melanoma - immunology Melanoma - mortality Melanoma - therapy Middle Aged Neoplasm Metastasis Original Reports Prospective Studies Whole-Body Irradiation
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