B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by an excessive inflammatory response within the lungs and severely impaired gas exchange resulting from alveolar-capillary barrier disruption and pulmonary edema. The costimulatory protein B7H3 functions as bot...

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Veröffentlicht in:	Scientific reports 2016-08, Vol.6 (1), p.31284-31284, Article 31284
Hauptverfasser:	Li, Yan, Huang, Jie, Foley, Niamh M., Xu, Yunyun, Li, Yi Ping, Pan, Jian, Redmond, H. Paul, Wang, Jiang Huai, Wang, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/31 13/95 631/250/256/1980 692/420/254 Acute Lung Injury - chemically induced Acute Lung Injury - metabolism Acute Lung Injury - pathology Acute Lung Injury - prevention & control Alveoli Animal models Animals B7 Antigens - pharmacology Bronchus Chemotaxis Costimulator CXCR2 protein Edema Gas exchange Humanities and Social Sciences Immune response Infiltration Inflammation Innate immunity Leukocyte migration Leukocytes (polymorphonuclear) Lipopolysaccharides Lipopolysaccharides - toxicity Lung - metabolism Lung - pathology Lungs Mac1 protein Male Meningitis Mice Mice, Inbred BALB C multidisciplinary Neutrophil Infiltration - drug effects Neutrophils Neutrophils - metabolism Neutrophils - pathology Peroxidase Phosphorylation Respiratory distress syndrome Respiratory therapy Rodents Science Sepsis
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