Tailoring sub-micron PLGA particle release profiles via centrifugal fractioning
Poly(D,L‐lactic‐co ‐glycolic) acid (PLGA)‐based sub‐micron particles are uniquely posed to overcome limitations of conventional drug delivery systems. However, tailoring cargo/payload release profiles from PLGA micro/nanoparticles typically requires optimization of the multi‐parameter formulation, w...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2016-03, Vol.104 (3), p.688-696 |
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| creator | Dutta, Dipankar Salifu, Mariama Sirianni, Rachael W. Stabenfeldt, Sarah E. |
| description | Poly(D,L‐lactic‐co ‐glycolic) acid (PLGA)‐based sub‐micron particles are uniquely posed to overcome limitations of conventional drug delivery systems. However, tailoring cargo/payload release profiles from PLGA micro/nanoparticles typically requires optimization of the multi‐parameter formulation, where small changes may cause drastic shifts in the resulting release profiles. In this study, we aimed to establish whether refining the average diameter of sub‐micron particle populations after formulation alters protein release profiles. PLGA particles were first produced via double emulsion‐solvent evaporation method to encapsulate bovine serum albumin. Particles were then subjected to centrifugal fractioning protocols varying in both spin time and force to determine encapsulation efficiency and release profile of differently sized populations that originated from a single batch. We found the average particle diameter was related to marked alterations in encapsulation efficiencies (range: 36.4–49.4%), burst release (range: 15.8–49.1%), and time for total cargo release (range: 38–78 days). Our data corroborate previous reports relating PLGA particle size with such release characteristics, however, this is the first study, to our knowledge, to directly compare particle population size while holding all formulation parameters constant. In summary, centrifugal fractioning to selectively control the population distribution of sub‐micron PLGA particles represents a feasible tool to tailor release characteristics. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A 104A: 688–696, 2016. |
| doi_str_mv | 10.1002/jbm.a.35608 |
| format | Article |
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However, tailoring cargo/payload release profiles from PLGA micro/nanoparticles typically requires optimization of the multi‐parameter formulation, where small changes may cause drastic shifts in the resulting release profiles. In this study, we aimed to establish whether refining the average diameter of sub‐micron particle populations after formulation alters protein release profiles. PLGA particles were first produced via double emulsion‐solvent evaporation method to encapsulate bovine serum albumin. Particles were then subjected to centrifugal fractioning protocols varying in both spin time and force to determine encapsulation efficiency and release profile of differently sized populations that originated from a single batch. We found the average particle diameter was related to marked alterations in encapsulation efficiencies (range: 36.4–49.4%), burst release (range: 15.8–49.1%), and time for total cargo release (range: 38–78 days). Our data corroborate previous reports relating PLGA particle size with such release characteristics, however, this is the first study, to our knowledge, to directly compare particle population size while holding all formulation parameters constant. In summary, centrifugal fractioning to selectively control the population distribution of sub‐micron PLGA particles represents a feasible tool to tailor release characteristics. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A 104A: 688–696, 2016.</description><identifier>ISSN: 1549-3296</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.35608</identifier><identifier>PMID: 26517011</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Atoms & subatomic particles ; Bovine serum albumin ; Bursting ; Cargo ; Cattle ; Centrifugal force ; centrifugal fractioning ; Centrifugation - methods ; Computing time ; Drug delivery ; Drug Delivery Systems ; Encapsulation ; Evaporation ; Feasibility ; Nanoparticles ; Optimization ; Particle Size ; Particle spin ; PLGA particles ; Polyglycolic Acid - chemistry ; Polylactide-co-glycolide ; Population distribution ; Population number ; protein encapsulation ; release profile ; Serum albumin ; Serum Albumin, Bovine - metabolism ; Time Factors</subject><ispartof>Journal of biomedical materials research. 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Part A</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Poly(D,L‐lactic‐co ‐glycolic) acid (PLGA)‐based sub‐micron particles are uniquely posed to overcome limitations of conventional drug delivery systems. However, tailoring cargo/payload release profiles from PLGA micro/nanoparticles typically requires optimization of the multi‐parameter formulation, where small changes may cause drastic shifts in the resulting release profiles. In this study, we aimed to establish whether refining the average diameter of sub‐micron particle populations after formulation alters protein release profiles. PLGA particles were first produced via double emulsion‐solvent evaporation method to encapsulate bovine serum albumin. Particles were then subjected to centrifugal fractioning protocols varying in both spin time and force to determine encapsulation efficiency and release profile of differently sized populations that originated from a single batch. We found the average particle diameter was related to marked alterations in encapsulation efficiencies (range: 36.4–49.4%), burst release (range: 15.8–49.1%), and time for total cargo release (range: 38–78 days). Our data corroborate previous reports relating PLGA particle size with such release characteristics, however, this is the first study, to our knowledge, to directly compare particle population size while holding all formulation parameters constant. In summary, centrifugal fractioning to selectively control the population distribution of sub‐micron PLGA particles represents a feasible tool to tailor release characteristics. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A 104A: 688–696, 2016.</description><subject>Animals</subject><subject>Atoms & subatomic particles</subject><subject>Bovine serum albumin</subject><subject>Bursting</subject><subject>Cargo</subject><subject>Cattle</subject><subject>Centrifugal force</subject><subject>centrifugal fractioning</subject><subject>Centrifugation - methods</subject><subject>Computing time</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Encapsulation</subject><subject>Evaporation</subject><subject>Feasibility</subject><subject>Nanoparticles</subject><subject>Optimization</subject><subject>Particle Size</subject><subject>Particle spin</subject><subject>PLGA particles</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Polylactide-co-glycolide</subject><subject>Population distribution</subject><subject>Population number</subject><subject>protein encapsulation</subject><subject>release profile</subject><subject>Serum albumin</subject><subject>Serum Albumin, Bovine - metabolism</subject><subject>Time Factors</subject><issn>1549-3296</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAURi0EoqWwYo8isUFCGfyIH9kgTStmAA1tBUUsrRvHHjwk8WAnhf573E47AhZd2ZKPj757P4SeEzwjGNM3m6afwYxxgdUDdEg4p2VVC_7w-l7VJaO1OEBPUtpkWGBOH6MDKjiRmJBDdHYBvgvRD-siTU3ZexPDUJyvlvNiC3H0prNFtJ2FZIttDM53NhWXHgpjhzF6N62hK1wEM_owZMtT9MhBl-yz2_MIfV28uzh5X67Olh9O5qvScKJUWTlVCwuCt86I1kHVqhwHgBqsqKNWqUY0DGNRMcJAWsdb2hrBG9OCakXNjtDbnXc7Nb1tb9JAp7fR9xCvdACv_30Z_He9Dpe6qhWmkmTBq1tBDD8nm0bd-2Rs18Fgw5Q0UVQIVkvGM_ryP3QTpjjk8TSpseQ5p2T3UlLk1XPJaKZe76i855SidfvIBOvrOnWuU4O-qTPTL_6ecs_e9ZcBugN-5WKu7nPpj8ef5nfWcvfJp9H-3n-C-EMLySTX306X-vzzgp5-WUjN2R87L7pv</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Dutta, Dipankar</creator><creator>Salifu, Mariama</creator><creator>Sirianni, Rachael W.</creator><creator>Stabenfeldt, Sarah E.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201603</creationdate><title>Tailoring sub-micron PLGA particle release profiles via centrifugal fractioning</title><author>Dutta, Dipankar ; Salifu, Mariama ; Sirianni, Rachael W. ; Stabenfeldt, Sarah E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5188-4f896ea65dfc6dfa4d8011aa2c082f2e88b6b30064313a7ef5d2dc65bcda8d693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Atoms & subatomic particles</topic><topic>Bovine serum albumin</topic><topic>Bursting</topic><topic>Cargo</topic><topic>Cattle</topic><topic>Centrifugal force</topic><topic>centrifugal fractioning</topic><topic>Centrifugation - methods</topic><topic>Computing time</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems</topic><topic>Encapsulation</topic><topic>Evaporation</topic><topic>Feasibility</topic><topic>Nanoparticles</topic><topic>Optimization</topic><topic>Particle Size</topic><topic>Particle spin</topic><topic>PLGA particles</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Polylactide-co-glycolide</topic><topic>Population distribution</topic><topic>Population number</topic><topic>protein encapsulation</topic><topic>release profile</topic><topic>Serum albumin</topic><topic>Serum Albumin, Bovine - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dutta, Dipankar</creatorcontrib><creatorcontrib>Salifu, Mariama</creatorcontrib><creatorcontrib>Sirianni, Rachael W.</creatorcontrib><creatorcontrib>Stabenfeldt, Sarah E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomedical materials research. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dutta, Dipankar</au><au>Salifu, Mariama</au><au>Sirianni, Rachael W.</au><au>Stabenfeldt, Sarah E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tailoring sub-micron PLGA particle release profiles via centrifugal fractioning</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2016-03</date><risdate>2016</risdate><volume>104</volume><issue>3</issue><spage>688</spage><epage>696</epage><pages>688-696</pages><issn>1549-3296</issn><eissn>1552-4965</eissn><abstract>Poly(D,L‐lactic‐co ‐glycolic) acid (PLGA)‐based sub‐micron particles are uniquely posed to overcome limitations of conventional drug delivery systems. However, tailoring cargo/payload release profiles from PLGA micro/nanoparticles typically requires optimization of the multi‐parameter formulation, where small changes may cause drastic shifts in the resulting release profiles. In this study, we aimed to establish whether refining the average diameter of sub‐micron particle populations after formulation alters protein release profiles. PLGA particles were first produced via double emulsion‐solvent evaporation method to encapsulate bovine serum albumin. Particles were then subjected to centrifugal fractioning protocols varying in both spin time and force to determine encapsulation efficiency and release profile of differently sized populations that originated from a single batch. We found the average particle diameter was related to marked alterations in encapsulation efficiencies (range: 36.4–49.4%), burst release (range: 15.8–49.1%), and time for total cargo release (range: 38–78 days). Our data corroborate previous reports relating PLGA particle size with such release characteristics, however, this is the first study, to our knowledge, to directly compare particle population size while holding all formulation parameters constant. In summary, centrifugal fractioning to selectively control the population distribution of sub‐micron PLGA particles represents a feasible tool to tailor release characteristics. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A 104A: 688–696, 2016.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26517011</pmid><doi>10.1002/jbm.a.35608</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of biomedical materials research. Part A, 2016-03, Vol.104 (3), p.688-696 |
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| subjects | Animals Atoms & subatomic particles Bovine serum albumin Bursting Cargo Cattle Centrifugal force centrifugal fractioning Centrifugation - methods Computing time Drug delivery Drug Delivery Systems Encapsulation Evaporation Feasibility Nanoparticles Optimization Particle Size Particle spin PLGA particles Polyglycolic Acid - chemistry Polylactide-co-glycolide Population distribution Population number protein encapsulation release profile Serum albumin Serum Albumin, Bovine - metabolism Time Factors |
| title | Tailoring sub-micron PLGA particle release profiles via centrifugal fractioning |
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