The nitroxyl donor, Angeli’s salt, reduces chronic constriction injury-induced neuropathic pain

Chronic pain is a major health problem worldwide. We have recently demonstrated the analgesic effect of the nitroxyl donor, Angeli’s salt (AS) in models of inflammatory pain. In the present study, the acute and chronic analgesic effects of AS was investigated in chronic constriction injury of the sc...

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Veröffentlicht in:	Chemico-biological interactions 2016-08, Vol.256, p.1-8
Hauptverfasser:	Longhi-Balbinot, Daniela T., Rossaneis, Ana C., Pinho-Ribeiro, Felipe A., Bertozzi, Mariana M., Cunha, Fernando Q., Alves-Filho, José C., Cunha, Thiago M., Peron, Jean P.S., Miranda, Katrina M., Casagrande, Rubia, Verri, Waldiceu A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Analgesics - administration & dosage Analgesics - therapeutic use Animals Astrocytes Astrocytes - drug effects Astrocytes - metabolism Astrocytes - pathology Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - metabolism Cytokines Gene Expression Regulation - drug effects Hyperalgesia - drug therapy Hyperalgesia - genetics Hyperalgesia - metabolism Hyperalgesia - physiopathology Interleukin-1beta - genetics Interleukin-33 - genetics Male Mice Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology Neuralgia - drug therapy Neuralgia - genetics Neuralgia - metabolism Neuralgia - physiopathology Neuropathic pain Neuroprotective Agents - administration & dosage Neuroprotective Agents - therapeutic use Nitrogen Oxides - administration & dosage Nitrogen Oxides - therapeutic use Nitroxyl donor Sciatic Nerve - drug effects Sciatic Nerve - physiopathology Signal Transduction - drug effects Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - physiopathology Tumor Necrosis Factor-alpha - genetics
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