Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment

Abstract Background Cell death due to anoikis, necrosis and cell egress from transplantation sites limits functional benefits of cellular cardiomyoplasty. Cell dissociation and suspension, which are a pre-requisite for most cell transplantation studies, lead to depression of cellular metabolism and...

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Veröffentlicht in:	Biomaterials 2015-12, Vol.73, p.1-11
Hauptverfasser:	Chan, Angel T, Karakas, Mehmet F, Vakrou, Styliani, Afzal, Junaid, Rittenbach, Andrew, Lin, Xiaoping, Wahl, Richard L, Pomper, Martin G, Steenbergen, Charles J, Tsui, Benjamin M.W, Elisseeff, Jennifer H, Abraham, M. Roselle
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Angiogenesis Animals Biocompatibility Biocompatible Materials - chemistry biodegradability bioluminescence Biomedical materials blood serum cardiac output Cell Adhesion Cell Proliferation Cell Survival Cell Transplantation crosslinking Dentistry dissociation Echocardiography Elastic Modulus Embryonic Stem Cells - cytology Encapsulation energy metabolism Engraftment Female Fluorodeoxyglucose F18 - chemistry genes glucose Glucose - chemistry HA:Serum hydrogels heart Heart - drug effects Heart - physiology Humans Hyaluronic Acid - chemistry hydrocolloids Hydrogels Hydrogels - chemistry image analysis in vitro studies In vivo testing Intercellular Signaling Peptides and Proteins - metabolism isotopes luciferase Male Mesenchymal Stromal Cells - cytology Metabolism Mice Molecular imaging Multimodal Imaging Myocardium - metabolism necrosis Neovascularization, Pathologic niches physical properties Rats Rats, Inbred WKY Stem Cell Transplantation - instrumentation Stem Cell Transplantation - methods Stem cells Stem Cells - cytology succinic acid Surgical implants symporters Tissue Engineering Tissue Scaffolds Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed viability
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