Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia
Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia.Retrospectively, medical records...
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| Veröffentlicht in: | Medicine (Baltimore) 2016-08, Vol.95 (31), p.e4375-e4375 |
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| creator | Jeon, Yong Duk Jeong, Woo Yong Kim, Moo Hyun Jung, In Young Ahn, Mi Young Ann, Hea Won Ahn, Jin Young Han, Sang Hoon Choi, Jun Yong Song, Young Goo Kim, June Myung Ku, Nam Su |
| description | Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia.Retrospectively, medical records from all patients with S. maltophilia bacteremia between December 2005 and 2014 at Severance Hospital, a 2000-bed tertiary care hospital in Seoul, Korea, were reviewed. Analysis was performed to identify factors associated with 28-day mortality.In total, 142 bacteremia patients were enrolled in this study. The overall 28-day mortality rate was 36.6%. Based on the univariate analysis, hematologic malignancy (P = 0.015), Sepsis-related Organ Failure Assessment (SOFA) score (P |
| doi_str_mv | 10.1097/MD.0000000000004375 |
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In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia.Retrospectively, medical records from all patients with S. maltophilia bacteremia between December 2005 and 2014 at Severance Hospital, a 2000-bed tertiary care hospital in Seoul, Korea, were reviewed. Analysis was performed to identify factors associated with 28-day mortality.In total, 142 bacteremia patients were enrolled in this study. The overall 28-day mortality rate was 36.6%. Based on the univariate analysis, hematologic malignancy (P = 0.015), Sepsis-related Organ Failure Assessment (SOFA) score (P < 0.001) and the removal of a central venous catheter (CVC) (P = 0.040) were significantly related to mortality. In the intensive care unit patients, the Acute Physiology and Chronic Health Evaluation II score (P = 0.001) also had significance. Based on the multivariate analysis, the SOFA score (odds ratio [OR] = 1.323; 95% confidence interval [CI]: 1.159, 1.509; P < 0.001) and removal of the CVC (OR = 0.330; 95% CI: 0.109, 0.996; P = 0.049) were independent factors associated with mortality.Our results suggest that removing a CVC may considerably reduce mortality in patients with S. maltophilia bacteremia.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000004375</identifier><identifier>PMID: 27495046</identifier><language>eng</language><publisher>United States: The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Age Factors ; Aged ; Catheterization, Central Venous - adverse effects ; Cause of Death ; Cohort Studies ; Cross Infection - etiology ; Cross Infection - mortality ; Databases, Factual ; Female ; Gram-Negative Bacterial Infections - etiology ; Gram-Negative Bacterial Infections - mortality ; Gram-Negative Bacterial Infections - physiopathology ; Hospital Mortality ; Humans ; Kaplan-Meier Estimate ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Observational Study ; Retrospective Studies ; Risk Assessment ; Sex Factors ; Stenotrophomonas maltophilia - immunology ; Survival Analysis ; Urinary Catheterization - adverse effects</subject><ispartof>Medicine (Baltimore), 2016-08, Vol.95 (31), p.e4375-e4375</ispartof><rights>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5002-f7a7e0436414bcd575afd4a1805054e2b7f9d4c89242755fc5527cfef13e42093</citedby><cites>FETCH-LOGICAL-c5002-f7a7e0436414bcd575afd4a1805054e2b7f9d4c89242755fc5527cfef13e42093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979800/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979800/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27495046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeon, Yong Duk</creatorcontrib><creatorcontrib>Jeong, Woo Yong</creatorcontrib><creatorcontrib>Kim, Moo Hyun</creatorcontrib><creatorcontrib>Jung, In Young</creatorcontrib><creatorcontrib>Ahn, Mi Young</creatorcontrib><creatorcontrib>Ann, Hea Won</creatorcontrib><creatorcontrib>Ahn, Jin Young</creatorcontrib><creatorcontrib>Han, Sang Hoon</creatorcontrib><creatorcontrib>Choi, Jun Yong</creatorcontrib><creatorcontrib>Song, Young Goo</creatorcontrib><creatorcontrib>Kim, June Myung</creatorcontrib><creatorcontrib>Ku, Nam Su</creatorcontrib><title>Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia.Retrospectively, medical records from all patients with S. maltophilia bacteremia between December 2005 and 2014 at Severance Hospital, a 2000-bed tertiary care hospital in Seoul, Korea, were reviewed. Analysis was performed to identify factors associated with 28-day mortality.In total, 142 bacteremia patients were enrolled in this study. The overall 28-day mortality rate was 36.6%. Based on the univariate analysis, hematologic malignancy (P = 0.015), Sepsis-related Organ Failure Assessment (SOFA) score (P < 0.001) and the removal of a central venous catheter (CVC) (P = 0.040) were significantly related to mortality. In the intensive care unit patients, the Acute Physiology and Chronic Health Evaluation II score (P = 0.001) also had significance. Based on the multivariate analysis, the SOFA score (odds ratio [OR] = 1.323; 95% confidence interval [CI]: 1.159, 1.509; P < 0.001) and removal of the CVC (OR = 0.330; 95% CI: 0.109, 0.996; P = 0.049) were independent factors associated with mortality.Our results suggest that removing a CVC may considerably reduce mortality in patients with S. maltophilia bacteremia.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Catheterization, Central Venous - adverse effects</subject><subject>Cause of Death</subject><subject>Cohort Studies</subject><subject>Cross Infection - etiology</subject><subject>Cross Infection - mortality</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Gram-Negative Bacterial Infections - etiology</subject><subject>Gram-Negative Bacterial Infections - mortality</subject><subject>Gram-Negative Bacterial Infections - physiopathology</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Observational Study</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Sex Factors</subject><subject>Stenotrophomonas maltophilia - immunology</subject><subject>Survival Analysis</subject><subject>Urinary Catheterization - adverse effects</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV9PHCEUxYmp0XXrJ2jS8NiX0QsDw_LSpNFWTdyY-OeZsCx0qMywBdaN317sqtHycgP33B8n5yL0hcARASmO56dH8O6wVvAdNCG87RouO_YJTQAob4QUbB8d5PwHgLSCsj20TwWTHFg3QTfXPt9jp02JKWMXEx5iKjr48oj9iFe6eDuWjDe-9Pim2DGWFFd9HOKoMx50KPXmg9d4URk22cHrz2jX6ZDt4UudortfP29PzpvLq7OLkx-XjeHVWeOEFrba7hhhC7Pkgmu3ZJrMgANnli6Ek0tmZpIyKjh3hnMqjLOOtJZRkO0Ufd9yV-vFYJemGk06qFXyg06PKmqvPnZG36vf8UExKeQMoAK-vQBS_Lu2uajBZ2ND0KON66yqFdkBI_RZ2m6lJsWck3Vv3xBQz-tQ81P1_zrq1Nf3Dt9mXvOvArYVbGKo6eX7sN7YpHpbg-3_8biQtKFAOpgBhaa-tLR9Ah6jluI</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Jeon, Yong Duk</creator><creator>Jeong, Woo Yong</creator><creator>Kim, Moo Hyun</creator><creator>Jung, In Young</creator><creator>Ahn, Mi Young</creator><creator>Ann, Hea Won</creator><creator>Ahn, Jin Young</creator><creator>Han, Sang Hoon</creator><creator>Choi, Jun Yong</creator><creator>Song, Young Goo</creator><creator>Kim, June Myung</creator><creator>Ku, Nam Su</creator><general>The Authors. 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All rights reserved</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160801</creationdate><title>Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia</title><author>Jeon, Yong Duk ; Jeong, Woo Yong ; Kim, Moo Hyun ; Jung, In Young ; Ahn, Mi Young ; Ann, Hea Won ; Ahn, Jin Young ; Han, Sang Hoon ; Choi, Jun Yong ; Song, Young Goo ; Kim, June Myung ; Ku, Nam Su</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5002-f7a7e0436414bcd575afd4a1805054e2b7f9d4c89242755fc5527cfef13e42093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Catheterization, Central Venous - adverse effects</topic><topic>Cause of Death</topic><topic>Cohort Studies</topic><topic>Cross Infection - etiology</topic><topic>Cross Infection - mortality</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Gram-Negative Bacterial Infections - etiology</topic><topic>Gram-Negative Bacterial Infections - mortality</topic><topic>Gram-Negative Bacterial Infections - physiopathology</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Observational Study</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Sex Factors</topic><topic>Stenotrophomonas maltophilia - immunology</topic><topic>Survival Analysis</topic><topic>Urinary Catheterization - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeon, Yong Duk</creatorcontrib><creatorcontrib>Jeong, Woo Yong</creatorcontrib><creatorcontrib>Kim, Moo Hyun</creatorcontrib><creatorcontrib>Jung, In Young</creatorcontrib><creatorcontrib>Ahn, Mi Young</creatorcontrib><creatorcontrib>Ann, Hea Won</creatorcontrib><creatorcontrib>Ahn, Jin Young</creatorcontrib><creatorcontrib>Han, Sang Hoon</creatorcontrib><creatorcontrib>Choi, Jun Yong</creatorcontrib><creatorcontrib>Song, Young Goo</creatorcontrib><creatorcontrib>Kim, June Myung</creatorcontrib><creatorcontrib>Ku, Nam Su</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeon, Yong Duk</au><au>Jeong, Woo Yong</au><au>Kim, Moo Hyun</au><au>Jung, In Young</au><au>Ahn, Mi Young</au><au>Ann, Hea Won</au><au>Ahn, Jin Young</au><au>Han, Sang Hoon</au><au>Choi, Jun Yong</au><au>Song, Young Goo</au><au>Kim, June Myung</au><au>Ku, Nam Su</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>95</volume><issue>31</issue><spage>e4375</spage><epage>e4375</epage><pages>e4375-e4375</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia.Retrospectively, medical records from all patients with S. maltophilia bacteremia between December 2005 and 2014 at Severance Hospital, a 2000-bed tertiary care hospital in Seoul, Korea, were reviewed. Analysis was performed to identify factors associated with 28-day mortality.In total, 142 bacteremia patients were enrolled in this study. The overall 28-day mortality rate was 36.6%. Based on the univariate analysis, hematologic malignancy (P = 0.015), Sepsis-related Organ Failure Assessment (SOFA) score (P < 0.001) and the removal of a central venous catheter (CVC) (P = 0.040) were significantly related to mortality. In the intensive care unit patients, the Acute Physiology and Chronic Health Evaluation II score (P = 0.001) also had significance. Based on the multivariate analysis, the SOFA score (odds ratio [OR] = 1.323; 95% confidence interval [CI]: 1.159, 1.509; P < 0.001) and removal of the CVC (OR = 0.330; 95% CI: 0.109, 0.996; P = 0.049) were independent factors associated with mortality.Our results suggest that removing a CVC may considerably reduce mortality in patients with S. maltophilia bacteremia.</abstract><cop>United States</cop><pub>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>27495046</pmid><doi>10.1097/MD.0000000000004375</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Aged Catheterization, Central Venous - adverse effects Cause of Death Cohort Studies Cross Infection - etiology Cross Infection - mortality Databases, Factual Female Gram-Negative Bacterial Infections - etiology Gram-Negative Bacterial Infections - mortality Gram-Negative Bacterial Infections - physiopathology Hospital Mortality Humans Kaplan-Meier Estimate Logistic Models Male Middle Aged Multivariate Analysis Observational Study Retrospective Studies Risk Assessment Sex Factors Stenotrophomonas maltophilia - immunology Survival Analysis Urinary Catheterization - adverse effects |
| title | Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia |
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