Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase

Necroptosis and signaling regulated by RIP1 kinase activity is emerging as a key driver of inflammation in a variety of disease settings. A significant amount has been learned about how RIP1 regulates necrotic cell death through the use of the RIP1 kinase inhibitor Necrostatin-1 (Nec-1). Nec-1 has b...

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Veröffentlicht in:	Cell death discovery 2015-07, Vol.1 (1), p.15009, Article 15009
Hauptverfasser:	Berger, SB, Harris, P, Nagilla, R, Kasparcova, V, Hoffman, S, Swift, B, Dare, L, Schaeffer, M, Capriotti, C, Ouellette, M, King, BW, Wisnoski, D, Cox, J, Reilly, M, Marquis, RW, Bertin, J, Gough, PJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Life Sciences Stem Cells
Online-Zugang:	Volltext
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