A Comparative Study of Lung Host Defense in Murine Obesity Models. Insights into Neutrophil Function

We have shown that obesity-associated attenuation of murine acute lung injury is driven, in part, by blunted neutrophil chemotaxis, yet differences were noted between the two models of obesity studied. We hypothesized that obesity-associated impairment of multiple neutrophil functions contributes to...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2016-08, Vol.55 (2), p.188-200
Hauptverfasser:	Ubags, Niki D J, Burg, Elianne, Antkowiak, Maryellen, Wallace, Aaron M, Dilli, Estee, Bement, Jenna, Wargo, Matthew J, Poynter, Matthew E, Wouters, Emiel F M, Suratt, Benjamin T
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Apoptosis - drug effects Bacterial infections Body mass index Bone marrow Cell Survival - drug effects Chemotaxis - drug effects Cytokines Cytokines - genetics Cytokines - metabolism Defects Diet Disease Models, Animal Fas Ligand Protein - pharmacology Granulocyte Colony-Stimulating Factor - pharmacology Host-Pathogen Interactions - drug effects Host-Pathogen Interactions - immunology Infections Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - physiology Laboratory animals Lipopolysaccharides Lung - drug effects Lung - microbiology Lung - pathology Metabolism Mice, Inbred C57BL Mitogen-Activated Protein Kinases - metabolism Mortality Multivariate analysis Neutrophils Neutrophils - drug effects Neutrophils - metabolism Neutrophils - pathology Obesity Obesity - complications Obesity - immunology Obesity - microbiology Obesity - pathology Original Research Pneumonia Pneumonia - complications Pneumonia - microbiology Pneumonia - pathology Respiratory distress syndrome Rodents Signal Transduction - drug effects Studies Transcription, Genetic - drug effects
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