Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells

Lung alveoli are lined by alveolar type (AT) 1 cells and cuboidal AT2 cells. The AT1 cells are likely to be exposed to cell-free hemoglobin (Hb) in multiple lung diseases; however, the role of Hb redox (reduction-oxidation) reactions and their precise contributions to AT1 cell injury are not well un...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2016-08, Vol.55 (2), p.288-298
Hauptverfasser:	Chintagari, Narendranath Reddy, Jana, Sirsendu, Alayash, Abdu I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alveolar Epithelial Cells - drug effects Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - pathology Animals Bioenergetics Cell culture Cell Line Heme Oxygenase-1 - metabolism Hemoglobin Hemoglobins - isolation & purification Hemoglobins - pharmacology Humans Investigations Iron - metabolism Laboratories Membrane Potential, Mitochondrial - drug effects Mice Mitochondria Mitochondria - drug effects Mitochondria - metabolism Models, Biological Original Research Oxidation-Reduction - drug effects Protein Transport - drug effects Proteins Rodents Sickle cell disease Up-Regulation - drug effects
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