miR-155 Deletion in Mice Overcomes Neuron-Intrinsic and Neuron-Extrinsic Barriers to Spinal Cord Repair

Axon regeneration after spinal cord injury (SCI) fails due to neuron-intrinsic mechanisms and extracellular barriers including inflammation. microRNA (miR)-155-5p is a small, noncoding RNA that negatively regulates mRNA translation. In macrophages, miR-155-5p is induced by inflammatory stimuli and e...

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Veröffentlicht in:	The Journal of neuroscience 2016-08, Vol.36 (32), p.8516-8532
Hauptverfasser:	Gaudet, Andrew D, Mandrekar-Colucci, Shweta, Hall, Jodie C E, Sweet, David R, Schmitt, Philipp J, Xu, Xinyang, Guan, Zhen, Mo, Xiaokui, Guerau-de-Arellano, Mireia, Popovich, Phillip G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons Calcium-Binding Proteins - metabolism Cells, Cultured Ganglia, Spinal - cytology Gene Expression Regulation - genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Lectins, C-Type - metabolism Mannose-Binding Lectins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Microfilament Proteins - metabolism MicroRNAs - genetics MicroRNAs - metabolism Neurites Neurons - physiology Receptors, Cell Surface - metabolism Sciatic Neuropathy - genetics Spinal Cord - cytology Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology Spinal Cord Regeneration - genetics Time Factors Transfection
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