SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens

Depression is a recurring and life-threatening illness that affects up to 120 million people worldwide. In the present study, we show that chronic social defeat stress, an ethologically validated model of depression in mice, increases SIRT1 levels in the nucleus accumbens (NAc), a key brain reward r...

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Veröffentlicht in:	The Journal of neuroscience 2016-08, Vol.36 (32), p.8441-8452
Hauptverfasser:	Kim, Hee-Dae, Hesterman, Jennifer, Call, Tanessa, Magazu, Samantha, Keeley, Elizabeth, Armenta, Kristyna, Kronman, Hope, Neve, Rachael L, Nestler, Eric J, Ferguson, Deveroux
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Carbazoles - pharmacology Carbazoles - therapeutic use Depression - drug therapy Depression - etiology Depression - metabolism Disease Models, Animal Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Drug Delivery Systems Exploratory Behavior - drug effects Exploratory Behavior - physiology Food Preferences - drug effects Food Preferences - physiology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Male Maze Learning - drug effects Maze Learning - physiology Mice Mice, Inbred C57BL Mice, Transgenic Nucleus Accumbens - cytology Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Receptors, Dopamine D1 Receptors, Dopamine D2 Sirtuin 1 - antagonists & inhibitors Sirtuin 1 - genetics Sirtuin 1 - metabolism Stress, Psychological - complications Stress, Psychological - metabolism Swimming - psychology
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