Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression

We previously found that the scaffold adapter GRB2-associated binding protein 2 (GAB2) is amplified and overexpressed in a subset of primary high-grade serous ovarian cancers and cell lines. Ovarian cancer cells overexpressing GAB2 are dependent on GAB2 for activation of the phosphatidylinositol 3-k...

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Veröffentlicht in:	Oncogene 2016-08, Vol.35 (31), p.4036-4047
Hauptverfasser:	Duckworth, C, Zhang, L, Carroll, S L, Ethier, S P, Cheung, H W
Format:	Artikel
Sprache:	eng
Schlagworte:	13 42/89 59 59/5 631/67/395 64 64/60 96 96/1 Adaptor Proteins, Signal Transducing - physiology Angiogenesis Animals Apoptosis Binding proteins Cancer Care and treatment Cell Biology Chemokine CXCL1 - genetics Chemokine CXCL2 - genetics Chemokines Chemokines - genetics Development and progression Endothelial Cells - physiology Female Gene expression Genetic aspects Health aspects Human Genetics Humans I-kappa B Kinase - physiology Interleukin-8 - genetics Internal Medicine Medicine Medicine & Public Health Mice Neovascularization, Pathologic - etiology NF-kappa B - physiology Oncology Original original-article Ovarian cancer Ovarian Neoplasms - blood supply Ovarian Neoplasms - pathology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Properties Signal transduction TOR Serine-Threonine Kinases - antagonists & inhibitors Up-Regulation
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