Dynamic contrast-enhanced MRI detects acute radiotherapy-induced alterations in mandibular microvasculature: prospective assessment of imaging biomarkers of normal tissue injury

Normal tissue toxicity is an important consideration in the continued development of more effective external beam radiotherapy (EBRT) regimens for head and neck tumors. The ability to detect EBRT-induced changes in mandibular bone vascularity represents a crucial step in decreasing potential toxicit...

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Veröffentlicht in:	Scientific reports 2016-08, Vol.6 (1), p.29864, Article 29864
Hauptverfasser:	Sandulache, Vlad C., Hobbs, Brian P., Mohamed, Abdallah S.R., Frank, Steven J., Song, Juhee, Ding, Yao, Ger, Rachel, Court, Laurence E., Kalpathy-Cramer, Jayashree, Hazle, John D., Wang, Jihong, Awan, Musaddiq J., Rosenthal, David I., Garden, Adam S., Gunn, G. Brandon, Colen, Rivka R., Elshafeey, Nabil, Elbanan, Mohamed, Hutcheson, Katherine A., Lewin, Jan S., Chambers, Mark S., Hofstede, Theresa M., Weber, Randal S., Lai, Stephen Y., Fuller, Clifton D.
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/53/2423 692/308/575 Abnormalities, Radiation-Induced - diagnostic imaging Biomarkers Biomarkers - metabolism Bone imaging Bone tumors Cancer Chemoradiotherapy Contrast Media Female Head & neck cancer Humanities and Social Sciences Humans Magnetic Resonance Imaging Male Mandible Mandible - blood supply Mandible - diagnostic imaging Microvasculature Microvessels - diagnostic imaging Microvessels - radiation effects Middle Aged multidisciplinary Oropharyngeal Neoplasms - diagnostic imaging Oropharyngeal Neoplasms - therapy Prospective Studies Radiation therapy Science Toxicity
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