Mechanisms of drug resistance in colon cancer and its therapeutic strategies

Drug resistance develops in nearly all patients with colon cancer, leading to a decrease in the therapeutic efficacies of anticancer agents. This review provides an up-to-date summary on over-expression of ATPbinding cassette(ABC) transporters and evasion of apoptosis, two representatives of transpo...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2016-08, Vol.22 (30), p.6876-6889
Hauptverfasser:	Hu, Tao, Li, Zhen, Gao, Chun-Ying, Cho, Chi Hin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis apoptosis Autophagy ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors ATP Binding Cassette Transporter, Sub-Family B - physiology ATP-Binding Cassette Transporters - analysis ATP-Binding Cassette Transporters - physiology Autophagy cancer Drug cassette Colon Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Drug Resistance, Neoplasm Humans resistance ATP-binding Review transporters Evasion Tumor Suppressor Protein p53 - physiology
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