Constitutive Endocytosis of VEGFR2 Protects the Receptor against Shedding

VEGFR2 plays a fundamental role in blood vessel formation and in life threatening diseases, such as cancer angiogenesis and cardiovascular disorders. Although inactive growth factor receptors are mainly localized at the plasma membrane, VEGFR2 undergoes constitutive endocytosis (in the absence of li...

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Veröffentlicht in:	The Journal of biological chemistry 2016-08, Vol.291 (32), p.16892-16903
Hauptverfasser:	Basagiannis, Dimitris, Christoforidis, Savvas
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Biology clathrin clathrin-mediated endocytosis dynamin endocytosis Endocytosis - physiology Human Umbilical Vein Endothelial Cells - metabolism Humans matrix metalloproteinase (MMP) membrane trafficking Protein Domains Protein Transport - physiology shedding signaling vascular endothelial growth factor (VEGF) Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism vascular endothelial growth factor receptor 2 Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism
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