Identification of a Noroxomaritidine Reductase with Amaryllidaceae Alkaloid Biosynthesis Related Activities

Amaryllidaceae alkaloids are a large group of plant natural products with over 300 documented structures and diverse biological activities. Several groups of Amaryllidaceae alkaloids including the hemanthamine- and crinine-type alkaloids show promise as anticancer agents. Two reduction reactions are...

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Veröffentlicht in:	The Journal of biological chemistry 2016-08, Vol.291 (32), p.16740-16752
Hauptverfasser:	Kilgore, Matthew B., Holland, Cynthia K., Jez, Joseph M., Kutchan, Toni M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amaryllidaceae alkaloids Amaryllidaceae Alkaloids - chemistry Amaryllidaceae Alkaloids - metabolism BASIC BIOLOGICAL SCIENCES crystal structure enzyme structure Galanthus - enzymology Galanthus - genetics Narcissus - enzymology Narcissus - genetics norbelladine noroxomaritidine reductase Oxidation-Reduction Oxidoreductases - chemistry Oxidoreductases - genetics Oxidoreductases - metabolism Plant Biology Plant Proteins - chemistry Plant Proteins - genetics Plant Proteins - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism reductase secondary metabolism transcriptomics
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