Proton pump inhibitors protect mice from acute systemic inflammation and induce long-term cross-tolerance

Incidence of sepsis is increasing, representing a tremendous burden for health-care systems. Death in acute sepsis is attributed to hyperinflammatory responses, but the underlying mechanisms are still unclear. We report here that proton pump inhibitors (PPIs), which block gastric acid secretion, sel...

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Veröffentlicht in:	Cell death & disease 2016-07, Vol.7 (7), p.e2304-e2304
Hauptverfasser:	Balza, E, Piccioli, P, Carta, S, Lavieri, R, Gattorno, M, Semino, C, Castellani, P, Rubartelli, A
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 38 45/29 631/250/127 631/250/256/1980 631/80 64/60 692/700/565/1436 Animals Antibodies Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cryopyrin-Associated Periodic Syndromes - genetics Cryopyrin-Associated Periodic Syndromes - immunology Cryopyrin-Associated Periodic Syndromes - pathology Esomeprazole - pharmacology Gene Expression Regulation Humans Immunology Inflammation Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - genetics Interleukin-1beta - immunology Life Sciences Lipopolysaccharides - toxicity Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Macrophages, Peritoneal - pathology Mice Mice, Inbred C57BL Monocytes - drug effects Monocytes - immunology Monocytes - pathology Omeprazole - pharmacology Original original-article Peritonitis - chemically induced Peritonitis - drug therapy Peritonitis - immunology Peritonitis - mortality Primary Cell Culture Proton Pump Inhibitors - pharmacology Rodents Sepsis Shock, Septic - chemically induced Shock, Septic - drug therapy Shock, Septic - immunology Shock, Septic - mortality Signal Transduction Survival Analysis Thioglycolates - administration & dosage Thioglycolates - antagonists & inhibitors Toll-Like Receptors - genetics Toll-Like Receptors - immunology Toxicity Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Zymosan - administration & dosage Zymosan - antagonists & inhibitors
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