A comprehensive analysis of 3' end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation

Alternative polyadenylation (APA) is a general mechanism of transcript diversification in mammals, which has been recently linked to proliferative states and cancer. Different 3' untranslated region (3' UTR) isoforms interact with different RNA-binding proteins (RBPs), which modify the sta...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Genome research 2016-08, Vol.26 (8), p.1145-1159
Hauptverfasser:	Gruber, Andreas J, Schmidt, Ralf, Gruber, Andreas R, Martin, Georges, Ghosh, Souvik, Belmadani, Manuel, Keller, Walter, Zavolan, Mihaela
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Animals Binding Sites Cytoplasm - genetics Gene Expression Heterogeneous-Nuclear Ribonucleoprotein Group C - genetics Humans Mice Polyadenylation - genetics Resource RNA, Messenger - genetics RNA-Binding Proteins - genetics Transcription, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!