Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer’s disease with OSBPL6, PTPRG, and PDCL3

The genetic basis of Alzheimer's disease (AD) is complex and heterogeneous. Over 200 highly penetrant pathogenic variants in the genes APP , PSEN1 , and PSEN2 cause a subset of early-onset familial AD. On the other hand, susceptibility to late-onset forms of AD (LOAD) is indisputably associated...

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Veröffentlicht in:	Molecular psychiatry 2016-11, Vol.21 (11), p.1608-1612
Hauptverfasser:	Herold, C, Hooli, B V, Mullin, K, Liu, T, Roehr, J T, Mattheisen, M, Parrado, A R, Bertram, L, Lange, C, Tanzi, R E
Format:	Artikel
Sprache:	eng
Schlagworte:	45/43 45/77 631/208 631/378 Age Age of Onset Aged Alleles Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E Apolipoproteins E - genetics Behavioral Sciences Biological Psychology Carrier Proteins - genetics Carrier Proteins - metabolism Family Female Genes Genetic Association Studies - methods Genetic factors Genetic Predisposition to Disease - genetics Genome-Wide Association Study - methods Genomes Genomics Genotype Heritability Humans Male Medicine Medicine & Public Health Meta-analysis Middle Aged Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurodegenerative diseases Neurosciences original-article Pharmacotherapy Phenotypes Polymorphism, Single Nucleotide Psychiatry Receptor-Like Protein Tyrosine Phosphatases, Class 5 - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 5 - metabolism Receptors, Steroid - genetics Receptors, Steroid - metabolism Risk Factors Single-nucleotide polymorphism Systematic review tRNA Methyltransferases - genetics tRNA Methyltransferases - metabolism
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