The Effect of Influenza Vaccination on Birth Outcomes in a Cohort of Pregnant Women in Lao PDR, 2014–2015
Background. Some studies suggest that maternal influenza vaccination can improve birth outcomes. However, there are limited data from tropical settings, particularly Southeast Asia. We conducted an observational study in Laos to assess the effect of influenza vaccination in pregnant women on birth o...
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| Veröffentlicht in: | Clinical infectious diseases 2016-08, Vol.63 (4), p.487-494 |
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| creator | Olsen, Sonja J. Mirza, Sara A. Vonglokham, Phouvanh Khanthamaly, Viengphone Chitry, Bounlap Pholsena, Vathsana Chitranonh, Visith Omer, Saad B. Moen, Ann Bresee, Joseph S. Corwin, Andrew Xeuatvongsa, Anonh |
| description | Background. Some studies suggest that maternal influenza vaccination can improve birth outcomes. However, there are limited data from tropical settings, particularly Southeast Asia. We conducted an observational study in Laos to assess the effect of influenza vaccination in pregnant women on birth outcomes. Methods. We consented and enrolled a cohort of pregnant woman who delivered babies at 3 hospitals during April 2014–February 2015. We collected demographic and clinical information on mother and child. Influenza vaccination status was ascertained by vaccine card. Primary outcomes were the proportion of live births born small for gestational age (SGA) or preterm and mean birth weight. Multivariate models controlled for differences between vaccinated and unvaccinated women and influenza virus circulation. Results. We enrolled 5103 women (2172 [43%] were vaccinated). Among the 4854 who had a live birth, vaccinated women were statistically significantly less likely than unvaccinated women to have an infant born preterm during the period of high influenza virus circulation (risk ratio [RR] = 0.56, 95% confidence interval [CI], .45–.70), and the effect remained after adjusting for covariates (adjusted RR, 0.69; 95% CI, .55–.87). There was no effect of vaccine on SGA or mean birth weight. The population-prevented fraction was 18.0%. Conclusions. In this observational study, we found indirect evidence of influenza vaccine safety during pregnancy, and women who received vaccine had a reduced risk of delivering a preterm infant during times of high influenza virus circulation. Vaccination may prevent 1 in 5 preterm births that occur during periods of high influenza circulation. |
| doi_str_mv | 10.1093/cid/ciw290 |
| format | Article |
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Some studies suggest that maternal influenza vaccination can improve birth outcomes. However, there are limited data from tropical settings, particularly Southeast Asia. We conducted an observational study in Laos to assess the effect of influenza vaccination in pregnant women on birth outcomes. Methods. We consented and enrolled a cohort of pregnant woman who delivered babies at 3 hospitals during April 2014–February 2015. We collected demographic and clinical information on mother and child. Influenza vaccination status was ascertained by vaccine card. Primary outcomes were the proportion of live births born small for gestational age (SGA) or preterm and mean birth weight. Multivariate models controlled for differences between vaccinated and unvaccinated women and influenza virus circulation. Results. We enrolled 5103 women (2172 [43%] were vaccinated). Among the 4854 who had a live birth, vaccinated women were statistically significantly less likely than unvaccinated women to have an infant born preterm during the period of high influenza virus circulation (risk ratio [RR] = 0.56, 95% confidence interval [CI], .45–.70), and the effect remained after adjusting for covariates (adjusted RR, 0.69; 95% CI, .55–.87). There was no effect of vaccine on SGA or mean birth weight. The population-prevented fraction was 18.0%. Conclusions. In this observational study, we found indirect evidence of influenza vaccine safety during pregnancy, and women who received vaccine had a reduced risk of delivering a preterm infant during times of high influenza virus circulation. Vaccination may prevent 1 in 5 preterm births that occur during periods of high influenza circulation.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciw290</identifier><identifier>PMID: 27143672</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adolescent ; Adult ; ARTICLES AND COMMENTARIES ; Cohort Studies ; Demographics ; Female ; Humans ; Immunization ; Infant, Newborn ; Infant, Premature ; Infant, Small for Gestational Age ; Influenza ; Influenza Vaccines - administration & dosage ; Influenza virus ; Influenza, Human - epidemiology ; Influenza, Human - prevention & control ; Laos - epidemiology ; Middle Aged ; Odds Ratio ; Pregnancy ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Complications, Infectious - prevention & control ; Premature birth ; Vaccination ; Young Adult</subject><ispartof>Clinical infectious diseases, 2016-08, Vol.63 (4), p.487-494</ispartof><rights>Copyright © 2016 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.</rights><rights>Copyright Oxford University Press, UK Aug 15, 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-903aba09b5b508310d8a737de50988b3f85df5d462a7e82ddbbedb40ef9d1b213</citedby><cites>FETCH-LOGICAL-c461t-903aba09b5b508310d8a737de50988b3f85df5d462a7e82ddbbedb40ef9d1b213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26371850$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26371850$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27143672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olsen, Sonja J.</creatorcontrib><creatorcontrib>Mirza, Sara A.</creatorcontrib><creatorcontrib>Vonglokham, Phouvanh</creatorcontrib><creatorcontrib>Khanthamaly, Viengphone</creatorcontrib><creatorcontrib>Chitry, Bounlap</creatorcontrib><creatorcontrib>Pholsena, Vathsana</creatorcontrib><creatorcontrib>Chitranonh, Visith</creatorcontrib><creatorcontrib>Omer, Saad B.</creatorcontrib><creatorcontrib>Moen, Ann</creatorcontrib><creatorcontrib>Bresee, Joseph S.</creatorcontrib><creatorcontrib>Corwin, Andrew</creatorcontrib><creatorcontrib>Xeuatvongsa, Anonh</creatorcontrib><title>The Effect of Influenza Vaccination on Birth Outcomes in a Cohort of Pregnant Women in Lao PDR, 2014–2015</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Background. Some studies suggest that maternal influenza vaccination can improve birth outcomes. However, there are limited data from tropical settings, particularly Southeast Asia. We conducted an observational study in Laos to assess the effect of influenza vaccination in pregnant women on birth outcomes. Methods. We consented and enrolled a cohort of pregnant woman who delivered babies at 3 hospitals during April 2014–February 2015. We collected demographic and clinical information on mother and child. Influenza vaccination status was ascertained by vaccine card. Primary outcomes were the proportion of live births born small for gestational age (SGA) or preterm and mean birth weight. Multivariate models controlled for differences between vaccinated and unvaccinated women and influenza virus circulation. Results. We enrolled 5103 women (2172 [43%] were vaccinated). Among the 4854 who had a live birth, vaccinated women were statistically significantly less likely than unvaccinated women to have an infant born preterm during the period of high influenza virus circulation (risk ratio [RR] = 0.56, 95% confidence interval [CI], .45–.70), and the effect remained after adjusting for covariates (adjusted RR, 0.69; 95% CI, .55–.87). There was no effect of vaccine on SGA or mean birth weight. The population-prevented fraction was 18.0%. Conclusions. In this observational study, we found indirect evidence of influenza vaccine safety during pregnancy, and women who received vaccine had a reduced risk of delivering a preterm infant during times of high influenza virus circulation. Vaccination may prevent 1 in 5 preterm births that occur during periods of high influenza circulation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>ARTICLES AND COMMENTARIES</subject><subject>Cohort Studies</subject><subject>Demographics</subject><subject>Female</subject><subject>Humans</subject><subject>Immunization</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Small for Gestational Age</subject><subject>Influenza</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza virus</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - prevention & control</subject><subject>Laos - epidemiology</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - epidemiology</subject><subject>Pregnancy Complications, Infectious - prevention & control</subject><subject>Premature birth</subject><subject>Vaccination</subject><subject>Young Adult</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EomVgwx5kiU2FCFzHcWxvkOhQoNJIrVCBpeW_dDJk7GInIFjxDrwhT4LDlPKzQrJ1LZ3P59r3IHSXwGMCkj6xvSv7Uy3hGtonjPKqZZJcL2dgomoEFXvoVs4bAEIEsJtor-akoS2v99H7s7XHR13n7Yhjh49DN0w-fNH4rba2D3rsY8BlHfZpXOOTabRx6zPuA9Z4Gdcx_bx2mvx50GHE74oaZnWlIz59_voRroE0379-K4XdRjc6PWR_57Iu0JsXR2fLV9Xq5OXx8tmqsk1LxkoC1UaDNMwwEJSAE5pT7jwDKYShnWCuY65pa829qJ0zxjvTgO-kI6YmdIGe7nwvJrP1zvowJj2oi9Rvdfqsou7V30ro1-o8flSN5CDLZBbo4NIgxQ-Tz6Pa9tn6YdDBxykrIgjjUDeE_wcKogVOa1nQB_-gmzilUCYxG86OVM69H-4om2LOyXdX7yag5rhViVvt4i7w_T9_eoX-yrcA93bAJo8x_dZbyolgQH8Awpau7w</recordid><startdate>20160815</startdate><enddate>20160815</enddate><creator>Olsen, Sonja J.</creator><creator>Mirza, Sara A.</creator><creator>Vonglokham, Phouvanh</creator><creator>Khanthamaly, Viengphone</creator><creator>Chitry, Bounlap</creator><creator>Pholsena, Vathsana</creator><creator>Chitranonh, Visith</creator><creator>Omer, Saad B.</creator><creator>Moen, Ann</creator><creator>Bresee, Joseph S.</creator><creator>Corwin, Andrew</creator><creator>Xeuatvongsa, Anonh</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7QO</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>20160815</creationdate><title>The Effect of Influenza Vaccination on Birth Outcomes in a Cohort of Pregnant Women in Lao PDR, 2014–2015</title><author>Olsen, Sonja J. ; Mirza, Sara A. ; Vonglokham, Phouvanh ; Khanthamaly, Viengphone ; Chitry, Bounlap ; Pholsena, Vathsana ; Chitranonh, Visith ; Omer, Saad B. ; Moen, Ann ; Bresee, Joseph S. ; Corwin, Andrew ; Xeuatvongsa, Anonh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-903aba09b5b508310d8a737de50988b3f85df5d462a7e82ddbbedb40ef9d1b213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>ARTICLES AND COMMENTARIES</topic><topic>Cohort Studies</topic><topic>Demographics</topic><topic>Female</topic><topic>Humans</topic><topic>Immunization</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Small for Gestational Age</topic><topic>Influenza</topic><topic>Influenza Vaccines - administration & dosage</topic><topic>Influenza virus</topic><topic>Influenza, Human - epidemiology</topic><topic>Influenza, Human - prevention & control</topic><topic>Laos - epidemiology</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - epidemiology</topic><topic>Pregnancy Complications, Infectious - prevention & control</topic><topic>Premature birth</topic><topic>Vaccination</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olsen, Sonja J.</creatorcontrib><creatorcontrib>Mirza, Sara A.</creatorcontrib><creatorcontrib>Vonglokham, Phouvanh</creatorcontrib><creatorcontrib>Khanthamaly, Viengphone</creatorcontrib><creatorcontrib>Chitry, Bounlap</creatorcontrib><creatorcontrib>Pholsena, Vathsana</creatorcontrib><creatorcontrib>Chitranonh, Visith</creatorcontrib><creatorcontrib>Omer, Saad B.</creatorcontrib><creatorcontrib>Moen, Ann</creatorcontrib><creatorcontrib>Bresee, Joseph S.</creatorcontrib><creatorcontrib>Corwin, Andrew</creatorcontrib><creatorcontrib>Xeuatvongsa, Anonh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olsen, Sonja J.</au><au>Mirza, Sara A.</au><au>Vonglokham, Phouvanh</au><au>Khanthamaly, Viengphone</au><au>Chitry, Bounlap</au><au>Pholsena, Vathsana</au><au>Chitranonh, Visith</au><au>Omer, Saad B.</au><au>Moen, Ann</au><au>Bresee, Joseph S.</au><au>Corwin, Andrew</au><au>Xeuatvongsa, Anonh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Influenza Vaccination on Birth Outcomes in a Cohort of Pregnant Women in Lao PDR, 2014–2015</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2016-08-15</date><risdate>2016</risdate><volume>63</volume><issue>4</issue><spage>487</spage><epage>494</epage><pages>487-494</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Background. Some studies suggest that maternal influenza vaccination can improve birth outcomes. However, there are limited data from tropical settings, particularly Southeast Asia. We conducted an observational study in Laos to assess the effect of influenza vaccination in pregnant women on birth outcomes. Methods. We consented and enrolled a cohort of pregnant woman who delivered babies at 3 hospitals during April 2014–February 2015. We collected demographic and clinical information on mother and child. Influenza vaccination status was ascertained by vaccine card. Primary outcomes were the proportion of live births born small for gestational age (SGA) or preterm and mean birth weight. Multivariate models controlled for differences between vaccinated and unvaccinated women and influenza virus circulation. Results. We enrolled 5103 women (2172 [43%] were vaccinated). Among the 4854 who had a live birth, vaccinated women were statistically significantly less likely than unvaccinated women to have an infant born preterm during the period of high influenza virus circulation (risk ratio [RR] = 0.56, 95% confidence interval [CI], .45–.70), and the effect remained after adjusting for covariates (adjusted RR, 0.69; 95% CI, .55–.87). There was no effect of vaccine on SGA or mean birth weight. The population-prevented fraction was 18.0%. Conclusions. In this observational study, we found indirect evidence of influenza vaccine safety during pregnancy, and women who received vaccine had a reduced risk of delivering a preterm infant during times of high influenza virus circulation. Vaccination may prevent 1 in 5 preterm births that occur during periods of high influenza circulation.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>27143672</pmid><doi>10.1093/cid/ciw290</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult ARTICLES AND COMMENTARIES Cohort Studies Demographics Female Humans Immunization Infant, Newborn Infant, Premature Infant, Small for Gestational Age Influenza Influenza Vaccines - administration & dosage Influenza virus Influenza, Human - epidemiology Influenza, Human - prevention & control Laos - epidemiology Middle Aged Odds Ratio Pregnancy Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - prevention & control Premature birth Vaccination Young Adult |
| title | The Effect of Influenza Vaccination on Birth Outcomes in a Cohort of Pregnant Women in Lao PDR, 2014–2015 |
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