Effect of intraperitoneal cetuximab administration on colonic anastomosis and early postoperative adhesion formation in a rat model
We aimed to evaluate the effect of intraperitoneal cetuximab administration on the healing of anastomosis and development of early adhesion formation in a rat model. Twenty-four female rats were used. A colon segment was resected and end-to-end anastomosis was performed. The rats were randomized int...
Gespeichert in:
| Veröffentlicht in: | Turkish journal of surgery 2016, Vol.32 (3), p.157-161 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 161 |
|---|---|
| container_issue | 3 |
| container_start_page | 157 |
| container_title | Turkish journal of surgery |
| container_volume | 32 |
| creator | Kurt, Atilla Karanlık, Hasan Soylu, Sinan Özgür, İlker Soydinç, Hilal Oğuz Duranyıldız, Derya Olgaç, Vakur Şen, Fatma Asoğlu, Oktar |
| description | We aimed to evaluate the effect of intraperitoneal cetuximab administration on the healing of anastomosis and development of early adhesion formation in a rat model.
Twenty-four female rats were used. A colon segment was resected and end-to-end anastomosis was performed. The rats were randomized into three groups after the performance of colonic anastomosis and received 10 mL of intraperitoneal solution including study drugs after closure of abdominal cavity: normal saline was administered to the normal saline group (n=8), cetuximab (400 mg/m(2)) was administered to the postoperative 1 group (n=8) 1 day after surgery, and cetuximab (400 mg/m(2)) was administered to the peroperative group (n=8) during surgery.
The mean adhesion grade was 2.63±0.92, and 0.50±0.76 and 0.63±0.74 for control and test groups, respectively. Cetuximab reduced adhesion formation in test groups (p |
| doi_str_mv | 10.5152/UCD.2016.3250 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4970771</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1812225273</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-1b2636b3030296f03bc1b64331ecca7b02404cae59ea8f527a39d12085c0a5523</originalsourceid><addsrcrecordid>eNpdkc1v1DAQxS0EolXpkSuyxIVLlrEdx8kFCS3lQ6rEhZ4tx5lQV4m92EnVnvnHmbClAixLHnl-8-ynx9hLATsttHx7tf-wkyCanZIanrBToaCtWi3F0981VGBAn7DzUm6AVlN3rYHn7EQaLdsWzCn7eTGO6BeeRh7ikt0Bc1hSRDdxj8t6F2bXczfMIYZC7SWkyGn7NKUYPHfRlSXNqYRC9cDR5emeHxJdkhLht0jT11i2uTHl-agQInec2nxOA04v2LPRTQXPH84zdvXx4tv-c3X59dOX_fvLytdCL5XoZaOaXoEC2TUjqN6LvqmVEui9Mz3IGmrvUHfo2lFL41Q3CAmt9uC0luqMvTvqHtZ-xsHjZniyh0wm871NLth_OzFc2-_p1tadAWMECbx5EMjpx4plsXMoHqfJRUxrsaIVUkp6WRH6-j_0Jq05kr2N6mpTgwaiqiPlcyol4_j4GQF2S9hSwnZL2G4JE__qbweP9J881S_I46OV</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1819474050</pqid></control><display><type>article</type><title>Effect of intraperitoneal cetuximab administration on colonic anastomosis and early postoperative adhesion formation in a rat model</title><source>PubMed Central</source><creator>Kurt, Atilla ; Karanlık, Hasan ; Soylu, Sinan ; Özgür, İlker ; Soydinç, Hilal Oğuz ; Duranyıldız, Derya ; Olgaç, Vakur ; Şen, Fatma ; Asoğlu, Oktar</creator><creatorcontrib>Kurt, Atilla ; Karanlık, Hasan ; Soylu, Sinan ; Özgür, İlker ; Soydinç, Hilal Oğuz ; Duranyıldız, Derya ; Olgaç, Vakur ; Şen, Fatma ; Asoğlu, Oktar</creatorcontrib><description>We aimed to evaluate the effect of intraperitoneal cetuximab administration on the healing of anastomosis and development of early adhesion formation in a rat model.
Twenty-four female rats were used. A colon segment was resected and end-to-end anastomosis was performed. The rats were randomized into three groups after the performance of colonic anastomosis and received 10 mL of intraperitoneal solution including study drugs after closure of abdominal cavity: normal saline was administered to the normal saline group (n=8), cetuximab (400 mg/m(2)) was administered to the postoperative 1 group (n=8) 1 day after surgery, and cetuximab (400 mg/m(2)) was administered to the peroperative group (n=8) during surgery.
The mean adhesion grade was 2.63±0.92, and 0.50±0.76 and 0.63±0.74 for control and test groups, respectively. Cetuximab reduced adhesion formation in test groups (p<0.05). When all groups were compared, it was found that vascular endothelial growth factor levels decreased significantly only in the abdomen (p<0.05). Hydroxyproline levels and anastomosis bursting pressure were examined, and a statistical difference was found between groups (hydroxyproline p<0.05, bursting pressure p<0.05). However, when postoperative 1 day group was compared with the control group, it was found that there was no difference between groups according to these parameters (p>0.05), but when peroperative group was compared with the control group a significant decrease was observed in both parameters. Histopathological healing score was also evaluated. No statistical difference between groups was found.
Twenty-four hours later from the operation, intraperitoneal cetuximab therapy may be a safe and feasible treatment for metastatic colorectal patients.</description><identifier>ISSN: 1300-0705</identifier><identifier>ISSN: 2564-6850</identifier><identifier>EISSN: 1308-8521</identifier><identifier>EISSN: 2564-7032</identifier><identifier>DOI: 10.5152/UCD.2016.3250</identifier><identifier>PMID: 27528807</identifier><language>eng</language><publisher>Turkey: Turkish Surgical Association</publisher><subject>Adhesion ; Anesthesia ; Cancer ; Cancer therapies ; Chemotherapy ; Laboratories ; Metastasis ; Original Investigation ; Postoperative period ; Rodents ; Surgery</subject><ispartof>Turkish journal of surgery, 2016, Vol.32 (3), p.157-161</ispartof><rights>Copyright Aves Yayincilik Ltd. STI. Sep 2016</rights><rights>Copyright 2016 by the Turkish Surgical Association 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-1b2636b3030296f03bc1b64331ecca7b02404cae59ea8f527a39d12085c0a5523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970771/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970771/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,4010,27904,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27528807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurt, Atilla</creatorcontrib><creatorcontrib>Karanlık, Hasan</creatorcontrib><creatorcontrib>Soylu, Sinan</creatorcontrib><creatorcontrib>Özgür, İlker</creatorcontrib><creatorcontrib>Soydinç, Hilal Oğuz</creatorcontrib><creatorcontrib>Duranyıldız, Derya</creatorcontrib><creatorcontrib>Olgaç, Vakur</creatorcontrib><creatorcontrib>Şen, Fatma</creatorcontrib><creatorcontrib>Asoğlu, Oktar</creatorcontrib><title>Effect of intraperitoneal cetuximab administration on colonic anastomosis and early postoperative adhesion formation in a rat model</title><title>Turkish journal of surgery</title><addtitle>Ulus Cerrahi Derg</addtitle><description>We aimed to evaluate the effect of intraperitoneal cetuximab administration on the healing of anastomosis and development of early adhesion formation in a rat model.
Twenty-four female rats were used. A colon segment was resected and end-to-end anastomosis was performed. The rats were randomized into three groups after the performance of colonic anastomosis and received 10 mL of intraperitoneal solution including study drugs after closure of abdominal cavity: normal saline was administered to the normal saline group (n=8), cetuximab (400 mg/m(2)) was administered to the postoperative 1 group (n=8) 1 day after surgery, and cetuximab (400 mg/m(2)) was administered to the peroperative group (n=8) during surgery.
The mean adhesion grade was 2.63±0.92, and 0.50±0.76 and 0.63±0.74 for control and test groups, respectively. Cetuximab reduced adhesion formation in test groups (p<0.05). When all groups were compared, it was found that vascular endothelial growth factor levels decreased significantly only in the abdomen (p<0.05). Hydroxyproline levels and anastomosis bursting pressure were examined, and a statistical difference was found between groups (hydroxyproline p<0.05, bursting pressure p<0.05). However, when postoperative 1 day group was compared with the control group, it was found that there was no difference between groups according to these parameters (p>0.05), but when peroperative group was compared with the control group a significant decrease was observed in both parameters. Histopathological healing score was also evaluated. No statistical difference between groups was found.
Twenty-four hours later from the operation, intraperitoneal cetuximab therapy may be a safe and feasible treatment for metastatic colorectal patients.</description><subject>Adhesion</subject><subject>Anesthesia</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Laboratories</subject><subject>Metastasis</subject><subject>Original Investigation</subject><subject>Postoperative period</subject><subject>Rodents</subject><subject>Surgery</subject><issn>1300-0705</issn><issn>2564-6850</issn><issn>1308-8521</issn><issn>2564-7032</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1v1DAQxS0EolXpkSuyxIVLlrEdx8kFCS3lQ6rEhZ4tx5lQV4m92EnVnvnHmbClAixLHnl-8-ynx9hLATsttHx7tf-wkyCanZIanrBToaCtWi3F0981VGBAn7DzUm6AVlN3rYHn7EQaLdsWzCn7eTGO6BeeRh7ikt0Bc1hSRDdxj8t6F2bXczfMIYZC7SWkyGn7NKUYPHfRlSXNqYRC9cDR5emeHxJdkhLht0jT11i2uTHl-agQInec2nxOA04v2LPRTQXPH84zdvXx4tv-c3X59dOX_fvLytdCL5XoZaOaXoEC2TUjqN6LvqmVEui9Mz3IGmrvUHfo2lFL41Q3CAmt9uC0luqMvTvqHtZ-xsHjZniyh0wm871NLth_OzFc2-_p1tadAWMECbx5EMjpx4plsXMoHqfJRUxrsaIVUkp6WRH6-j_0Jq05kr2N6mpTgwaiqiPlcyol4_j4GQF2S9hSwnZL2G4JE__qbweP9J881S_I46OV</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Kurt, Atilla</creator><creator>Karanlık, Hasan</creator><creator>Soylu, Sinan</creator><creator>Özgür, İlker</creator><creator>Soydinç, Hilal Oğuz</creator><creator>Duranyıldız, Derya</creator><creator>Olgaç, Vakur</creator><creator>Şen, Fatma</creator><creator>Asoğlu, Oktar</creator><general>Turkish Surgical Association</general><general>Turkish Journal of Surgery</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2016</creationdate><title>Effect of intraperitoneal cetuximab administration on colonic anastomosis and early postoperative adhesion formation in a rat model</title><author>Kurt, Atilla ; Karanlık, Hasan ; Soylu, Sinan ; Özgür, İlker ; Soydinç, Hilal Oğuz ; Duranyıldız, Derya ; Olgaç, Vakur ; Şen, Fatma ; Asoğlu, Oktar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-1b2636b3030296f03bc1b64331ecca7b02404cae59ea8f527a39d12085c0a5523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adhesion</topic><topic>Anesthesia</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Laboratories</topic><topic>Metastasis</topic><topic>Original Investigation</topic><topic>Postoperative period</topic><topic>Rodents</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurt, Atilla</creatorcontrib><creatorcontrib>Karanlık, Hasan</creatorcontrib><creatorcontrib>Soylu, Sinan</creatorcontrib><creatorcontrib>Özgür, İlker</creatorcontrib><creatorcontrib>Soydinç, Hilal Oğuz</creatorcontrib><creatorcontrib>Duranyıldız, Derya</creatorcontrib><creatorcontrib>Olgaç, Vakur</creatorcontrib><creatorcontrib>Şen, Fatma</creatorcontrib><creatorcontrib>Asoğlu, Oktar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Turkey Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Turkish journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurt, Atilla</au><au>Karanlık, Hasan</au><au>Soylu, Sinan</au><au>Özgür, İlker</au><au>Soydinç, Hilal Oğuz</au><au>Duranyıldız, Derya</au><au>Olgaç, Vakur</au><au>Şen, Fatma</au><au>Asoğlu, Oktar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of intraperitoneal cetuximab administration on colonic anastomosis and early postoperative adhesion formation in a rat model</atitle><jtitle>Turkish journal of surgery</jtitle><addtitle>Ulus Cerrahi Derg</addtitle><date>2016</date><risdate>2016</risdate><volume>32</volume><issue>3</issue><spage>157</spage><epage>161</epage><pages>157-161</pages><issn>1300-0705</issn><issn>2564-6850</issn><eissn>1308-8521</eissn><eissn>2564-7032</eissn><abstract>We aimed to evaluate the effect of intraperitoneal cetuximab administration on the healing of anastomosis and development of early adhesion formation in a rat model.
Twenty-four female rats were used. A colon segment was resected and end-to-end anastomosis was performed. The rats were randomized into three groups after the performance of colonic anastomosis and received 10 mL of intraperitoneal solution including study drugs after closure of abdominal cavity: normal saline was administered to the normal saline group (n=8), cetuximab (400 mg/m(2)) was administered to the postoperative 1 group (n=8) 1 day after surgery, and cetuximab (400 mg/m(2)) was administered to the peroperative group (n=8) during surgery.
The mean adhesion grade was 2.63±0.92, and 0.50±0.76 and 0.63±0.74 for control and test groups, respectively. Cetuximab reduced adhesion formation in test groups (p<0.05). When all groups were compared, it was found that vascular endothelial growth factor levels decreased significantly only in the abdomen (p<0.05). Hydroxyproline levels and anastomosis bursting pressure were examined, and a statistical difference was found between groups (hydroxyproline p<0.05, bursting pressure p<0.05). However, when postoperative 1 day group was compared with the control group, it was found that there was no difference between groups according to these parameters (p>0.05), but when peroperative group was compared with the control group a significant decrease was observed in both parameters. Histopathological healing score was also evaluated. No statistical difference between groups was found.
Twenty-four hours later from the operation, intraperitoneal cetuximab therapy may be a safe and feasible treatment for metastatic colorectal patients.</abstract><cop>Turkey</cop><pub>Turkish Surgical Association</pub><pmid>27528807</pmid><doi>10.5152/UCD.2016.3250</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1300-0705 |
| ispartof | Turkish journal of surgery, 2016, Vol.32 (3), p.157-161 |
| issn | 1300-0705 2564-6850 1308-8521 2564-7032 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4970771 |
| source | PubMed Central |
| subjects | Adhesion Anesthesia Cancer Cancer therapies Chemotherapy Laboratories Metastasis Original Investigation Postoperative period Rodents Surgery |
| title | Effect of intraperitoneal cetuximab administration on colonic anastomosis and early postoperative adhesion formation in a rat model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T16%3A09%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20intraperitoneal%20cetuximab%20administration%20on%20colonic%20anastomosis%20and%20early%20postoperative%20adhesion%20formation%20in%20a%20rat%20model&rft.jtitle=Turkish%20journal%20of%20surgery&rft.au=Kurt,%20Atilla&rft.date=2016&rft.volume=32&rft.issue=3&rft.spage=157&rft.epage=161&rft.pages=157-161&rft.issn=1300-0705&rft.eissn=1308-8521&rft_id=info:doi/10.5152/UCD.2016.3250&rft_dat=%3Cproquest_pubme%3E1812225273%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1819474050&rft_id=info:pmid/27528807&rfr_iscdi=true |