Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol‐dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation

ABSTRACT Biliverdin reductase A (BVR) and Akt isozymes have overlapping pleiotropic functions in the insulin/PI3K/MAPK pathway. Human BVR (hBVR) also reduces the hemeoxygenase activity product biliverdin to bilirubin and is directly activated by insulin receptor kinase (IRK). Akt isoenzymes (Akt1‐3)...

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Veröffentlicht in:	The FASEB journal 2016-08, Vol.30 (8), p.2926-2944
Hauptverfasser:	Miralem, Tihomir, Lerner‐Marmarosh, Nicole, Gibbs, Peter E. M., Jenkins, Jermaine L., Heimiller, Chelsea, Maines, Mahin D.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Phosphoinositide-Dependent Protein Kinases - genetics 3-Phosphoinositide-Dependent Protein Kinases - metabolism activation of hBVR Akt/hBVR/GSK3 axis Amino Acid Sequence bilirubin Gene Expression Regulation - physiology Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism HEK293 Cells heme oxygenase 1 Humans Oxidoreductases Acting on CH-CH Group Donors - genetics Oxidoreductases Acting on CH-CH Group Donors - metabolism Phosphorylation Protein Binding Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal Transduction
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