Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis
Metastasis-associated in colon cancer-1(MACC1) is an oncogene that was first identified in colon cancer. The upstream and downstream of MACC1 form a delicate regulatory network that supports its tumorigenic role in cancers. Multiple functions of MACC1 have been discovered in many cancers. In gastric...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2016-08, Vol.22 (29), p.6629-6637 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Wu, Zhen-Zhen Chen, Li-Shan Zhou, Rui Bin, Jian-Ping Liao, Yu-Lin Liao, Wang-Jun |
| description | Metastasis-associated in colon cancer-1(MACC1) is an oncogene that was first identified in colon cancer. The upstream and downstream of MACC1 form a delicate regulatory network that supports its tumorigenic role in cancers. Multiple functions of MACC1 have been discovered in many cancers. In gastric cancer(GC), MACC1 has been shown to be involved in oncogenesis and t umor progression. MACC1 overexpression adversely affects the clinical outcomes of GC patients. Regarding the mechanism of action of MACC1 in GC, studies have shown that it promotes the epithelialto-mesenchymal transition and accelerates cancer metastasis. MACC1 is involved in many hallmarks of GC in addition to metastasis. MACC1 promotes vasculogenic mimicry(VM) via TWIST1/2, and VM increases the tumor blood supply, which is necessary for tumor progression. MACC1 also facilitates GC lymphangiogenesis by upregulating extracellular secretion of VEGF-C/D, indicating that MACC1 may be an important player in GC lymphatic dissemination. Additionally, MACC1 supports GC growth under metabolic stress by enhancing the Warburg effect. In conclusion, MACC1 participates in multiple biological processes inside and outside of GC cells, making it an important mediator of the tumor microenvironment. |
| doi_str_mv | 10.3748/wjg.v22.i29.6629 |
| format | Article |
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The upstream and downstream of MACC1 form a delicate regulatory network that supports its tumorigenic role in cancers. Multiple functions of MACC1 have been discovered in many cancers. In gastric cancer(GC), MACC1 has been shown to be involved in oncogenesis and t umor progression. MACC1 overexpression adversely affects the clinical outcomes of GC patients. Regarding the mechanism of action of MACC1 in GC, studies have shown that it promotes the epithelialto-mesenchymal transition and accelerates cancer metastasis. MACC1 is involved in many hallmarks of GC in addition to metastasis. MACC1 promotes vasculogenic mimicry(VM) via TWIST1/2, and VM increases the tumor blood supply, which is necessary for tumor progression. MACC1 also facilitates GC lymphangiogenesis by upregulating extracellular secretion of VEGF-C/D, indicating that MACC1 may be an important player in GC lymphatic dissemination. Additionally, MACC1 supports GC growth under metabolic stress by enhancing the Warburg effect. In conclusion, MACC1 participates in multiple biological processes inside and outside of GC cells, making it an important mediator of the tumor microenvironment.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v22.i29.6629</identifier><identifier>PMID: 27547006</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>cancer-1;Gastric ; cancer;Epithelial-to-mesenchymal ; colon ; Epigenesis, Genetic ; Epithelial-Mesenchymal Transition ; Humans ; Lymphangiogenesis ; Metastasis-associated ; Proto-Oncogene Proteins c-met - physiology ; Stomach Neoplasms - etiology ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Topic Highlight ; Transcription Factors - blood ; Transcription Factors - genetics ; Transcription Factors - physiology ; transition;Vasculog ; Tumor Microenvironment</subject><ispartof>World journal of gastroenterology : WJG, 2016-08, Vol.22 (29), p.6629-6637</ispartof><rights>The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-ab913aa13968cacd94bbcc546ed6621ae5d33a670ad59edc22ca32da135d860f3</citedby><cites>FETCH-LOGICAL-c510t-ab913aa13968cacd94bbcc546ed6621ae5d33a670ad59edc22ca32da135d860f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970472/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970472/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27547006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Zhen-Zhen</creatorcontrib><creatorcontrib>Chen, Li-Shan</creatorcontrib><creatorcontrib>Zhou, Rui</creatorcontrib><creatorcontrib>Bin, Jian-Ping</creatorcontrib><creatorcontrib>Liao, Yu-Lin</creatorcontrib><creatorcontrib>Liao, Wang-Jun</creatorcontrib><title>Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>Metastasis-associated in colon cancer-1(MACC1) is an oncogene that was first identified in colon cancer. The upstream and downstream of MACC1 form a delicate regulatory network that supports its tumorigenic role in cancers. Multiple functions of MACC1 have been discovered in many cancers. In gastric cancer(GC), MACC1 has been shown to be involved in oncogenesis and t umor progression. MACC1 overexpression adversely affects the clinical outcomes of GC patients. Regarding the mechanism of action of MACC1 in GC, studies have shown that it promotes the epithelialto-mesenchymal transition and accelerates cancer metastasis. MACC1 is involved in many hallmarks of GC in addition to metastasis. MACC1 promotes vasculogenic mimicry(VM) via TWIST1/2, and VM increases the tumor blood supply, which is necessary for tumor progression. MACC1 also facilitates GC lymphangiogenesis by upregulating extracellular secretion of VEGF-C/D, indicating that MACC1 may be an important player in GC lymphatic dissemination. Additionally, MACC1 supports GC growth under metabolic stress by enhancing the Warburg effect. In conclusion, MACC1 participates in multiple biological processes inside and outside of GC cells, making it an important mediator of the tumor microenvironment.</description><subject>cancer-1;Gastric</subject><subject>cancer;Epithelial-to-mesenchymal</subject><subject>colon</subject><subject>Epigenesis, Genetic</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Humans</subject><subject>Lymphangiogenesis</subject><subject>Metastasis-associated</subject><subject>Proto-Oncogene Proteins c-met - physiology</subject><subject>Stomach Neoplasms - etiology</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Topic Highlight</subject><subject>Transcription Factors - blood</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - physiology</subject><subject>transition;Vasculog</subject><subject>Tumor Microenvironment</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLAzEUhYMoWqt7V9Klm6k3z5m4ELT4goobXYfbJB0j04lOpkr_vSnWoiEkcPOdc5McQk4ojHkpqvOvt3r8ydg4MD1WiukdMmCM6oJVAnbJgAKUheasPCCHKb0BMM4l2ycHrJSiBFADMn30PaY8QyowpWgD9t6NQjuysYl5xdb6rqDrSp3BLthN7WJ07VexdaPF1uGI7M2xSf54sw_Jy-3N8-S-mD7dPUyupoWVFPoCZ5pyRMq1qixap8VsZq0Uyrv8CIpeOs5RlYBOau8sYxY5c1kgXaVgzofk8sf3fTlbZMC3fYeNee_CAruViRjM_5M2vJo6fhqhSxAlywZnG4Mufix96s0iJOubBlsfl8nQinLFpOQ8o_CD2i6m1Pn5tg0Fsw7B5BBMDsHkEMw6hCw5_Xu9reD31zPAN56vsa0_QltvGQ3VemgJohJaCgky9xCVVPwb4hSVBw</recordid><startdate>20160807</startdate><enddate>20160807</enddate><creator>Wu, Zhen-Zhen</creator><creator>Chen, Li-Shan</creator><creator>Zhou, Rui</creator><creator>Bin, Jian-Ping</creator><creator>Liao, Yu-Lin</creator><creator>Liao, Wang-Jun</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160807</creationdate><title>Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis</title><author>Wu, Zhen-Zhen ; Chen, Li-Shan ; Zhou, Rui ; Bin, Jian-Ping ; Liao, Yu-Lin ; Liao, Wang-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-ab913aa13968cacd94bbcc546ed6621ae5d33a670ad59edc22ca32da135d860f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>cancer-1;Gastric</topic><topic>cancer;Epithelial-to-mesenchymal</topic><topic>colon</topic><topic>Epigenesis, Genetic</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Humans</topic><topic>Lymphangiogenesis</topic><topic>Metastasis-associated</topic><topic>Proto-Oncogene Proteins c-met - physiology</topic><topic>Stomach Neoplasms - etiology</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Topic Highlight</topic><topic>Transcription Factors - blood</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - physiology</topic><topic>transition;Vasculog</topic><topic>Tumor Microenvironment</topic><toplevel>online_resources</toplevel><creatorcontrib>Wu, Zhen-Zhen</creatorcontrib><creatorcontrib>Chen, Li-Shan</creatorcontrib><creatorcontrib>Zhou, Rui</creatorcontrib><creatorcontrib>Bin, Jian-Ping</creatorcontrib><creatorcontrib>Liao, Yu-Lin</creatorcontrib><creatorcontrib>Liao, Wang-Jun</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Zhen-Zhen</au><au>Chen, Li-Shan</au><au>Zhou, Rui</au><au>Bin, Jian-Ping</au><au>Liao, Yu-Lin</au><au>Liao, Wang-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2016-08-07</date><risdate>2016</risdate><volume>22</volume><issue>29</issue><spage>6629</spage><epage>6637</epage><pages>6629-6637</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>Metastasis-associated in colon cancer-1(MACC1) is an oncogene that was first identified in colon cancer. The upstream and downstream of MACC1 form a delicate regulatory network that supports its tumorigenic role in cancers. Multiple functions of MACC1 have been discovered in many cancers. In gastric cancer(GC), MACC1 has been shown to be involved in oncogenesis and t umor progression. MACC1 overexpression adversely affects the clinical outcomes of GC patients. Regarding the mechanism of action of MACC1 in GC, studies have shown that it promotes the epithelialto-mesenchymal transition and accelerates cancer metastasis. MACC1 is involved in many hallmarks of GC in addition to metastasis. MACC1 promotes vasculogenic mimicry(VM) via TWIST1/2, and VM increases the tumor blood supply, which is necessary for tumor progression. MACC1 also facilitates GC lymphangiogenesis by upregulating extracellular secretion of VEGF-C/D, indicating that MACC1 may be an important player in GC lymphatic dissemination. Additionally, MACC1 supports GC growth under metabolic stress by enhancing the Warburg effect. In conclusion, MACC1 participates in multiple biological processes inside and outside of GC cells, making it an important mediator of the tumor microenvironment.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>27547006</pmid><doi>10.3748/wjg.v22.i29.6629</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | cancer-1 Gastric cancer Epithelial-to-mesenchymal colon Epigenesis, Genetic Epithelial-Mesenchymal Transition Humans Lymphangiogenesis Metastasis-associated Proto-Oncogene Proteins c-met - physiology Stomach Neoplasms - etiology Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Topic Highlight Transcription Factors - blood Transcription Factors - genetics Transcription Factors - physiology transition Vasculog Tumor Microenvironment |
| title | Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis |
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