Relationship between fasting glucose levels and in-hospital mortality in Chinese patients with acute myocardial infarction and diabetes mellitus: a retrospective cohort study

Previous studies have demonstrated that elevated admission and fasting glucose (FG) is associated with worse outcomes in patients with acute myocardial infarction (AMI). However, the quantitative relationship between FG levels and in-hospital mortality in patients with AMI remains unknown. The aim o...

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Veröffentlicht in:BMC cardiovascular disorders 2016-08, Vol.16 (1), p.156-156, Article 156
Hauptverfasser: Liang, Hao, Guo, Yi Chen, Chen, Li Ming, Li, Min, Han, Wei Zhong, Zhang, Xu, Jiang, Shi Liang
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container_start_page 156
container_title BMC cardiovascular disorders
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creator Liang, Hao
Guo, Yi Chen
Chen, Li Ming
Li, Min
Han, Wei Zhong
Zhang, Xu
Jiang, Shi Liang
description Previous studies have demonstrated that elevated admission and fasting glucose (FG) is associated with worse outcomes in patients with acute myocardial infarction (AMI). However, the quantitative relationship between FG levels and in-hospital mortality in patients with AMI remains unknown. The aim of the study is to assess the prevalence of elevated FG levels in hospitalized Chinese patients with AMI and diabetes mellitus and to determine the quantitative relationship between FG levels and the in-hospital mortality as well as the optimal level of FG in patients with AMI and diabetes mellitus. A retrospective study was carried out in 1856 consecutive patients admitted for AMI and diabetes mellitus from 2002 to 2013. Clinical variables of baseline characteristics, in-hospital management and in-hospital adverse outcomes were recorded and compared among patients with different FG levels. Among all patients recruited, 993 patients (53.5 %) were found to have FG ≥100 mg/dL who exhibited a higher in-hospital mortality than those with FG 
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However, the quantitative relationship between FG levels and in-hospital mortality in patients with AMI remains unknown. The aim of the study is to assess the prevalence of elevated FG levels in hospitalized Chinese patients with AMI and diabetes mellitus and to determine the quantitative relationship between FG levels and the in-hospital mortality as well as the optimal level of FG in patients with AMI and diabetes mellitus. A retrospective study was carried out in 1856 consecutive patients admitted for AMI and diabetes mellitus from 2002 to 2013. Clinical variables of baseline characteristics, in-hospital management and in-hospital adverse outcomes were recorded and compared among patients with different FG levels. Among all patients recruited, 993 patients (53.5 %) were found to have FG ≥100 mg/dL who exhibited a higher in-hospital mortality than those with FG &lt; 100 mg/dL (P &lt; 0.001). Although there was a high correlation between FG levels and in-hospital mortality in all patients (r = 0.830, P &lt; 0.001), the relationship showed a J-curve configuration with an elevated mortality when FG was less than 80 mg/dL. Using multivariate logistic regression models, we identified that age, FG levels and Killip class of cardiac function were independent predictors of in-hospital mortality in AMI patients with diabetes mellitus. More than half of patients with AMI and diabetes mellitus have FG ≥100 mg/dL and the relationship between in-hospital mortality and FG level was a J-curve configuration. Both FG ≥ 100 mg/dL and FG &lt;80 mg/dL were identified to be independent predictors of in-hospital mortality and thus the optimal FG level in AMI patients with diabetes mellitus appears to be 80-100 mg/dL.</description><identifier>ISSN: 1471-2261</identifier><identifier>EISSN: 1471-2261</identifier><identifier>DOI: 10.1186/s12872-016-0331-2</identifier><identifier>PMID: 27484985</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis ; Biomarkers - blood ; Blood Glucose - metabolism ; Cardiac patients ; Care and treatment ; Chi-Square Distribution ; China - epidemiology ; Complications and side effects ; Dextrose ; Diabetes ; Diabetes Mellitus - blood ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - mortality ; Diabetes Mellitus - therapy ; Fasting - blood ; Female ; Glucose ; Health aspects ; Heart attack ; Hospital Mortality ; Hospitalization ; Humans ; Incidence ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Myocardial Infarction - blood ; Myocardial Infarction - diagnosis ; Myocardial Infarction - mortality ; Myocardial Infarction - therapy ; Odds Ratio ; Patient outcomes ; Prevalence ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors</subject><ispartof>BMC cardiovascular disorders, 2016-08, Vol.16 (1), p.156-156, Article 156</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-9377c931c5da56ec2d4ab2c9f7d9b2941c38b9a82507913e4e5d98c0284e4483</citedby><cites>FETCH-LOGICAL-c494t-9377c931c5da56ec2d4ab2c9f7d9b2941c38b9a82507913e4e5d98c0284e4483</cites><orcidid>0000-0002-9043-5416</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969715/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969715/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27484985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Hao</creatorcontrib><creatorcontrib>Guo, Yi Chen</creatorcontrib><creatorcontrib>Chen, Li Ming</creatorcontrib><creatorcontrib>Li, Min</creatorcontrib><creatorcontrib>Han, Wei Zhong</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Jiang, Shi Liang</creatorcontrib><title>Relationship between fasting glucose levels and in-hospital mortality in Chinese patients with acute myocardial infarction and diabetes mellitus: a retrospective cohort study</title><title>BMC cardiovascular disorders</title><addtitle>BMC Cardiovasc Disord</addtitle><description>Previous studies have demonstrated that elevated admission and fasting glucose (FG) is associated with worse outcomes in patients with acute myocardial infarction (AMI). However, the quantitative relationship between FG levels and in-hospital mortality in patients with AMI remains unknown. The aim of the study is to assess the prevalence of elevated FG levels in hospitalized Chinese patients with AMI and diabetes mellitus and to determine the quantitative relationship between FG levels and the in-hospital mortality as well as the optimal level of FG in patients with AMI and diabetes mellitus. A retrospective study was carried out in 1856 consecutive patients admitted for AMI and diabetes mellitus from 2002 to 2013. Clinical variables of baseline characteristics, in-hospital management and in-hospital adverse outcomes were recorded and compared among patients with different FG levels. Among all patients recruited, 993 patients (53.5 %) were found to have FG ≥100 mg/dL who exhibited a higher in-hospital mortality than those with FG &lt; 100 mg/dL (P &lt; 0.001). Although there was a high correlation between FG levels and in-hospital mortality in all patients (r = 0.830, P &lt; 0.001), the relationship showed a J-curve configuration with an elevated mortality when FG was less than 80 mg/dL. Using multivariate logistic regression models, we identified that age, FG levels and Killip class of cardiac function were independent predictors of in-hospital mortality in AMI patients with diabetes mellitus. More than half of patients with AMI and diabetes mellitus have FG ≥100 mg/dL and the relationship between in-hospital mortality and FG level was a J-curve configuration. Both FG ≥ 100 mg/dL and FG &lt;80 mg/dL were identified to be independent predictors of in-hospital mortality and thus the optimal FG level in AMI patients with diabetes mellitus appears to be 80-100 mg/dL.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Cardiac patients</subject><subject>Care and treatment</subject><subject>Chi-Square Distribution</subject><subject>China - epidemiology</subject><subject>Complications and side effects</subject><subject>Dextrose</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Diabetes Mellitus - mortality</subject><subject>Diabetes Mellitus - therapy</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Heart attack</subject><subject>Hospital Mortality</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Incidence</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - therapy</subject><subject>Odds Ratio</subject><subject>Patient outcomes</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Time Factors</subject><issn>1471-2261</issn><issn>1471-2261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUs1q3DAQNqWlSdM-QC9F0EsvTiVZtqUeCmHpHwQKJXchy-O1gi1tJXnDvlSfseNuGjal6DBi9P0wo68oXjN6yZhs3ifGZctLypqSVhUr-ZPinIkWL7xhT0_uZ8WLlG4pZa2k6nlxxlshhZL1efHrB0wmu-DT6Hakg3wH4MlgUnZ-S7bTYkMCMsEepkSM74nz5RjSzmUzkTlELC4fsEs2o_OA2B3Kgc-J3Lk8EmOXDGQ-BGti75Dj_GCiXR3_yGEPTSGRGSZUWtIHYkiEHNEDELYHYsOIPiTlpT-8LJ4NZkrw6r5eFDefP91svpbX379821xdl1YokUtVta1VFbN1b-oGLO-F6bhVQ9urjivBbCU7ZSSvaatYBQLqXklLuRQghKwuio9H2d3SzdBbnCeaSe-im0086GCcfvzi3ai3Ya-FalTLahR4dy8Qw88FUtazSxZHNB7CkjTDf6BCUqYQ-vYf6G1YosfpEMUaxRtRn6C2ZgKNSwzoa1dRfSUaKVlF5Wp7-R8Unh5mZ4OHwWH_EYEdCRYXniIMDzMyqteM6WPGNGZMrxnTHDlvTpfzwPgbquo3_Q7Qrg</recordid><startdate>20160802</startdate><enddate>20160802</enddate><creator>Liang, Hao</creator><creator>Guo, Yi Chen</creator><creator>Chen, Li Ming</creator><creator>Li, Min</creator><creator>Han, Wei Zhong</creator><creator>Zhang, Xu</creator><creator>Jiang, Shi Liang</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9043-5416</orcidid></search><sort><creationdate>20160802</creationdate><title>Relationship between fasting glucose levels and in-hospital mortality in Chinese patients with acute myocardial infarction and diabetes mellitus: a retrospective cohort study</title><author>Liang, Hao ; 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However, the quantitative relationship between FG levels and in-hospital mortality in patients with AMI remains unknown. The aim of the study is to assess the prevalence of elevated FG levels in hospitalized Chinese patients with AMI and diabetes mellitus and to determine the quantitative relationship between FG levels and the in-hospital mortality as well as the optimal level of FG in patients with AMI and diabetes mellitus. A retrospective study was carried out in 1856 consecutive patients admitted for AMI and diabetes mellitus from 2002 to 2013. Clinical variables of baseline characteristics, in-hospital management and in-hospital adverse outcomes were recorded and compared among patients with different FG levels. Among all patients recruited, 993 patients (53.5 %) were found to have FG ≥100 mg/dL who exhibited a higher in-hospital mortality than those with FG &lt; 100 mg/dL (P &lt; 0.001). Although there was a high correlation between FG levels and in-hospital mortality in all patients (r = 0.830, P &lt; 0.001), the relationship showed a J-curve configuration with an elevated mortality when FG was less than 80 mg/dL. Using multivariate logistic regression models, we identified that age, FG levels and Killip class of cardiac function were independent predictors of in-hospital mortality in AMI patients with diabetes mellitus. More than half of patients with AMI and diabetes mellitus have FG ≥100 mg/dL and the relationship between in-hospital mortality and FG level was a J-curve configuration. Both FG ≥ 100 mg/dL and FG &lt;80 mg/dL were identified to be independent predictors of in-hospital mortality and thus the optimal FG level in AMI patients with diabetes mellitus appears to be 80-100 mg/dL.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27484985</pmid><doi>10.1186/s12872-016-0331-2</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9043-5416</orcidid><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Analysis
Biomarkers - blood
Blood Glucose - metabolism
Cardiac patients
Care and treatment
Chi-Square Distribution
China - epidemiology
Complications and side effects
Dextrose
Diabetes
Diabetes Mellitus - blood
Diabetes Mellitus - diagnosis
Diabetes Mellitus - mortality
Diabetes Mellitus - therapy
Fasting - blood
Female
Glucose
Health aspects
Heart attack
Hospital Mortality
Hospitalization
Humans
Incidence
Logistic Models
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocardial Infarction - mortality
Myocardial Infarction - therapy
Odds Ratio
Patient outcomes
Prevalence
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
title Relationship between fasting glucose levels and in-hospital mortality in Chinese patients with acute myocardial infarction and diabetes mellitus: a retrospective cohort study
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