Combining Stimulus-Triggered Release and Active Targeting Strategies Improves Cytotoxicity of Cytochrome c Nanoparticles in Tumor Cells

Proteins often possess highly specific biological activities that make them potential therapeutics, but their physical and chemical instabilities during formulation, storage, and delivery have limited their medical use. Therefore, engineering of nanosized vehicles to stabilize protein therapeutics a...

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Veröffentlicht in:	Molecular pharmaceutics 2016-08, Vol.13 (8), p.2844-2854
Hauptverfasser:	Morales-Cruz, Moraima, Cruz-Montañez, Alejandra, Figueroa, Cindy M, González-Robles, Tania, Davila, Josue, Inyushin, Mikhail, Loza-Rosas, Sergio A, Molina, Anna M, Muñoz-Perez, Laura, Kucheryavykh, Lilia Y, Tinoco, Arthur D, Griebenow, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Apoptosis Cytochromes c - chemistry Cytochromes c - metabolism Drug Carriers - chemistry Drug Delivery Systems - methods Glioma - metabolism HeLa Cells Humans Mice Mice, Inbred C57BL Micelles Nanoparticles - chemistry Nanoparticles - metabolism NIH 3T3 Cells Polymers - chemistry
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