Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation

Low extracellular pH promotes in melanoma cells a malignant phenotype characterized by an epithelial-to-mesenchymal transition (EMT) program, endowed with mesenchymal markers, high invasiveness and pro-metastatic property. Here, we demonstrate that melanoma cells exposed to an acidic extracellular m...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2016-07, Vol.15 (14), p.1908-1918
Hauptverfasser:	Peppicelli, Silvia, Toti, Alessandra, Giannoni, Elisa, Bianchini, Francesca, Margheri, Francesca, Del Rosso, Mario, Calorini, Lido
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis, Lactic - pathology Adaptation, Physiological - drug effects Cell Death - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Coumaric Acids - pharmacology Culture Media Humans Lactates - metabolism Lactates - pharmacology Melanoma - metabolism Melanoma - pathology Mesoderm - drug effects Mesoderm - metabolism Metabolomics Metformin - pharmacology Oxidative Phosphorylation - drug effects Phenotype Tumor Stem Cell Assay
Online-Zugang:	Volltext
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