Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model

PD-1 (programmed-death 1), an immune-inhibitory receptor required for immune self-tolerance whose deficiency causes autoimmunity with variable severity and tissue specificity depending on other genetic factors, is expressed on activated T cells, including the transcription factor FoxP3⁺ Treg cells k...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2016-07, Vol.113 (30), p.8490-8495
Hauptverfasser: Zhang, Baihao, Chikuma, Shunsuke, Hori, Shohei, Fagarasan, Sidonia, Honjo, Tasuku
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Sprache:eng
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