Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis

The adult mammalian brain is a dynamic structure, capable of remodeling in response to various physiological and pathological stimuli. One dramatic example of brain plasticity is the birth and subsequent integration of newborn neurons into the existing circuitry. This process, termed adult neurogene...

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Veröffentlicht in:	Cold Spring Harbor perspectives in biology 2016-08, Vol.8 (8), p.a018937
Hauptverfasser:	Song, Juan, Olsen, Reid H J, Sun, Jiaqi, Ming, Guo-Li, Song, Hongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Hippocampus - cytology Hippocampus - physiology Humans Neurogenesis - physiology Neurons - physiology
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creator	Song, Juan Olsen, Reid H J Sun, Jiaqi Ming, Guo-Li Song, Hongjun
description	The adult mammalian brain is a dynamic structure, capable of remodeling in response to various physiological and pathological stimuli. One dramatic example of brain plasticity is the birth and subsequent integration of newborn neurons into the existing circuitry. This process, termed adult neurogenesis, recapitulates neural developmental events in two specialized adult brain regions: the lateral ventricles of the forebrain. Recent studies have begun to delineate how the existing neuronal circuits influence the dynamic process of adult neurogenesis, from activation of quiescent neural stem cells (NSCs) to the integration and survival of newborn neurons. Here, we review recent progress toward understanding the circuit-based regulation of adult neurogenesis in the hippocampus and olfactory bulb.
doi_str_mv	10.1101/cshperspect.a018937
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subjects	Animals Hippocampus - cytology Hippocampus - physiology Humans Neurogenesis - physiology Neurons - physiology
title	Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis
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