Prolonged maternal separation induces undernutrition and systemic inflammation with disrupted hippocampal development in mice

Abstract Objective Prolonged maternal separation (PMS) in the first two weeks of life has been associated with poor growth with lasting effects in the brain structure and function. This study aimed to investigate whether PMS-induced undernutrition could cause systemic inflammation and changes in nut...

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Veröffentlicht in:	Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2016-09, Vol.32 (9), p.1019-1027
Hauptverfasser:	Figueiredo, Ítalo Leite, DVM, PhD, Frota, Priscila B., MD, da Cunha, Davi G., MSc, da Silva Raposo, Ramon, DVM, PhD, Canuto, Kildere M., MSc, de Andrade, Geanne M., PhD, Sousa, Nuno, MD, PhD, Moore, Sean R., MD, PhD, Anstead, Gregory M., MD, Alvarez-Leite, Jacqueline I., MD, PhD, Guerrant, Richard L., MD, Oriá, Reinaldo B., DVM, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	adiponectin Amino acids Amino Acids - blood Animals Animals, Newborn aspartic acid blood serum brain Breastfeeding & lactation Colleges & universities corticosterone Disease Models, Animal gamma-aminobutyric acid Gastroenterology and Hepatology glutamic acid Hippocampus Hippocampus - growth & development Hippocampus - physiopathology IGF-1 Inflammation Inflammation - blood Inflammation - etiology insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Laboratories lactation Leptin Malnutrition Malnutrition - blood Malnutrition - etiology Maternal Deprivation Maternal separation Mice Mice, Inbred C57BL myelin basic protein ontogeny pups reflexes Rodents Stereology suckling
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