Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells

Coupling of an intracellular Ca(2+) clock to surface membrane ion channels, i.e., a "membrane clock, " via coupling of electrochemical Na(+) and Ca(2+) gradients (ENa and ECa, respectively) has been theorized to regulate sinoatrial nodal cell (SANC) normal automaticity. To test this hypoth...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2016-07, Vol.311 (1), p.H251-H267
Hauptverfasser:	Sirenko, Syevda G, Maltsev, Victor A, Yaniv, Yael, Bychkov, Rostislav, Yaeger, Daniel, Vinogradova, Tatiana, Spurgeon, Harold A, Lakatta, Edward G
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Biological Clocks - drug effects Calcium - metabolism Calcium Channels - metabolism Calcium Signaling - drug effects Cardiac Excitation and Contraction Computer Simulation Digoxigenin - pharmacology Epithelial Sodium Channels - metabolism Heart Rate - drug effects In Vitro Techniques Male Models, Cardiovascular Numerical Analysis, Computer-Assisted Periodicity Rabbits Sinoatrial Node - cytology Sinoatrial Node - drug effects Sinoatrial Node - metabolism Sodium - metabolism Sodium-Calcium Exchanger - metabolism Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!