Impact of high-fat, low-carbohydrate diet on myocardial substrate oxidation, insulin sensitivity, and cardiac function after ischemia-reperfusion

High-fat, low-carbohydrate Diet (HFLCD) impairs the myocardial response to ischemia-reperfusion, but the underlying mechanisms remain elusive. We sought to determine the magnitude of diet-induced alterations in intrinsic properties of the myocardium (including insulin sensitivity and substrate oxida...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2016-07, Vol.311 (1), p.H1-H10
Hauptverfasser:	Liu, Jian, Wang, Peipei, Douglas, Samuel L, Tate, Joshua M, Sham, Simon, Lloyd, Steven G
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid - pharmacology Animals Call for Papers Carbohydrates Citric Acid Cycle Diet Diet, Carbohydrate-Restricted - adverse effects Diet, High-Fat - adverse effects Dose-Response Relationship, Drug Energy Metabolism - drug effects Fatty acids Fatty Acids, Nonesterified - metabolism Insulin - pharmacology Insulin Resistance Ischemia Isolated Heart Preparation Male Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oxidation Oxidation-Reduction Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Rats, Sprague-Dawley Recovery of Function Ventricular Function, Left
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