The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage

Purpose Ionizing radiation (IR) generates reactive oxygen species (ROS), which cause DNA double-strand breaks (DSBs) that are responsible for cytogenetic alterations. Because antioxidants are potent ROS scavengers, we determined whether the vitamin E isoform γ-tocotrienol (GT3), a radio-protective m...

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Veröffentlicht in:	Pharmaceutical research 2016-09, Vol.33 (9), p.2117-2125
Hauptverfasser:	Pathak, Rupak, Bachri, Abdel, Ghosh, Sanchita P., Koturbash, Igor, Boerma, Marjan, Binz, Regina K., Sawyer, Jeffrey R., Hauer-Jensen, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antioxidants - administration & dosage Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Bone Marrow Cells - drug effects Cells, Cultured Chromosome Aberrations - drug effects Cytogenetics DNA Breaks, Double-Stranded - drug effects DNA damage DNA polymerases DNA repair DNA Repair - drug effects DNA Repair Enzymes - genetics Female Gene expression Genes Health aspects Human exposure Human Umbilical Vein Endothelial Cells - drug effects Humans Medical Law Mice Mice, Inbred C57BL Pharmacology/Toxicology Pharmacy Radiation Radiation Injuries - drug therapy Radiation, Ionizing Research Paper Tocotrienols - administration & dosage Vitamin E Vitamin E - administration & dosage
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