Pyruvate dehydrogenase kinase regulates hepatitis C virus replication

During replication, hepatitis C virus (HCV) utilizes macromolecules produced by its host cell. This process requires host cellular metabolic reprogramming to favor elevated levels of aerobic glycolysis. Therefore, we evaluated whether pyruvate dehydrogenase kinase (PDK), a mitochondrial enzyme that...

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Veröffentlicht in:	Scientific reports 2016-07, Vol.6 (1), p.30846-30846, Article 30846
Hauptverfasser:	Jung, Gwon-Soo, Jeon, Jae-Han, Choi, Yeon-Kyung, Jang, Se Young, Park, Soo Young, Kim, Sung-Woo, Byun, Jun-Kyu, Kim, Mi-Kyung, Lee, Sungwoo, Shin, Eui-Cheol, Lee, In-Kyu, Kang, Yu Na, Park, Keun-Gyu
Format:	Artikel
Sprache:	eng
Schlagworte:	14/34 38/89 631/326/596/1905 631/80/304 692/4020/4021/234/2513/1551 82/80 Adult Aged Antiviral Agents - pharmacology Azepines - pharmacology Cell Line Dichloroacetic Acid - pharmacology Glucokinase - metabolism Glycolysis Hepacivirus - physiology Hepatocytes - cytology Hepatocytes - metabolism Hepatocytes - virology Humanities and Social Sciences Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Interferon-alpha - pharmacology Liver - metabolism Liver - pathology Liver - virology Middle Aged multidisciplinary Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-myc - antagonists & inhibitors Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Ribavirin - pharmacology RNA Interference Science Triazoles - pharmacology Virus Replication - drug effects Virus Replication - physiology
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