Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Malignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on de novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. The nuclear receptor liver-X-receptor (LXR) directly regulates expression of key glycolytic and lipogenic genes. To disru...

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Veröffentlicht in:	Cancer cell 2015-07, Vol.28 (1), p.42-56
Hauptverfasser:	Flaveny, Colin A., Griffett, Kristine, El-Gendy, Bahaa El-Dien M., Kazantzis, Melissa, Sengupta, Monideepa, Amelio, Antonio L., Chatterjee, Arindam, Walker, John, Solt, Laura A., Kamenecka, Theodore M., Burris, Thomas P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Cell Line, Tumor Glycolysis - drug effects Hep G2 Cells HT29 Cells Humans Lipogenesis - drug effects Liver X Receptors Mice Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - pathology Organ Specificity Orphan Nuclear Receptors - agonists Small Molecule Libraries - administration & dosage Small Molecule Libraries - pharmacology Sulfonamides - administration & dosage Sulfonamides - pharmacology Weight Loss - drug effects Xenograft Model Antitumor Assays
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