Update in restless legs syndrome
Although restless legs syndrome (RLS) is a disorder recognized in the medical literature since the 17th century, there have only recently been significant clinical and scientific advances in diagnosis, epidemiology and understanding the disorder, mainly due to the advent of dopaminergic treatment. R...
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| Veröffentlicht in: | Current opinion in neurology 2010-08, Vol.23 (4), p.401-406 |
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| container_title | Current opinion in neurology |
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| creator | Salas, Rachel E Gamaldo, Charlene E Allen, Richard P |
| description | Although restless legs syndrome (RLS) is a disorder recognized in the medical literature since the 17th century, there have only recently been significant clinical and scientific advances in diagnosis, epidemiology and understanding the disorder, mainly due to the advent of dopaminergic treatment.
Recent discoveries have uncovered the iron-dopamine connection in RLS and the basic dopaminergic pathology related to the RLS symptoms. These have led to new understanding of the morbidity of RLS and the many conditions associated with RLS, which have also supported new approaches to treatment. These developments are each briefly described here.
Although there has been progress in understanding, diagnosing and treating RLS, it remains an underdiagnosed and undertreated condition severely impairing functioning of patients with moderate-to-severe disease. Much work is needed to improve on current, as well as other novel therapies. |
| doi_str_mv | 10.1097/WCO.0b013e32833bcdd8 |
| format | Article |
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Recent discoveries have uncovered the iron-dopamine connection in RLS and the basic dopaminergic pathology related to the RLS symptoms. These have led to new understanding of the morbidity of RLS and the many conditions associated with RLS, which have also supported new approaches to treatment. These developments are each briefly described here.
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Recent discoveries have uncovered the iron-dopamine connection in RLS and the basic dopaminergic pathology related to the RLS symptoms. These have led to new understanding of the morbidity of RLS and the many conditions associated with RLS, which have also supported new approaches to treatment. These developments are each briefly described here.
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| ispartof | Current opinion in neurology, 2010-08, Vol.23 (4), p.401-406 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Brain - drug effects Brain - metabolism Brain - physiopathology Humans Iron Metabolism Disorders - complications Iron Metabolism Disorders - metabolism Iron Metabolism Disorders - physiopathology Iron Metabolism Disorders - therapy Randomized Controlled Trials as Topic Restless Legs Syndrome - diagnosis Restless Legs Syndrome - epidemiology Restless Legs Syndrome - physiopathology Restless Legs Syndrome - therapy Substantia Nigra - metabolism Substantia Nigra - physiopathology |
| title | Update in restless legs syndrome |
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