Mesothelin, a novel immunotherapy target for triple negative breast cancer

Mesothelin is a cell-surface glycoprotein present on mesothelial cells and elicits T cell responses in a variety of cancers including pancreatic, biliary and ovarian cancer. Breast cancer is not known to express mesothelin. We postulated that mesothelin may be a unique tumor-associated antigen in tr...

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Veröffentlicht in:	Breast cancer research and treatment 2012-06, Vol.133 (2), p.799-804
Hauptverfasser:	Tchou, Julia, Wang, Liang-Chuan, Selven, Ben, Zhang, Hongtao, Conejo-Garcia, Jose, Borghaei, Hossein, Kalos, Michael, Vondeheide, Robert H., Albelda, Steven M., June, Carl H., Zhang, Paul J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism Biological and medical sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - therapy Brief Report Cancer research Cancer therapies Cell Line, Tumor Cohort Studies Drug therapy Female Formaldehyde Genetically modified organisms Glycoproteins GPI-Linked Proteins - immunology GPI-Linked Proteins - metabolism Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Immunotherapy Mammary gland diseases Medical sciences Medicine Medicine & Public Health Oncology Ovarian cancer Receptor, ErbB-2 - deficiency Receptors, Estrogen - deficiency Receptors, Progesterone - deficiency T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism Transduction, Genetic Tumors
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