Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain Injury

Cerebral white and grey matter injury is the leading cause of an adverse neurodevelopmental outcome in prematurely born infants. High oxygen concentrations have been shown to contribute to the pathogenesis of neonatal brain damage. Here, we focused on motor-cognitive outcome up to the adolescent and...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-13
Hauptverfasser:	Endesfelder, Stefanie, Fandrey, Joachim, Felderhoff-Mueser, Ursula, Bendix, Ivo, Palasz, Joanna, Serdar, Meray, Kempe, Karina, Sizonenko, Stéphane V., Herz, Josephine, van de Looij, Yohan, Sifringer, Marco, Hoeber, Daniela, Hadamitzky, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animal cognition Animals Animals, Newborn Attention Deficit Hyperactivity Disorder Behavior, Animal - drug effects Brain Brain damage Brain Injuries - etiology Brain Injuries - metabolism Brain Injuries - pathology Cell Survival - drug effects Clinical trials Cognition - drug effects Diffusion Tensor Imaging Disease Models, Animal Down-Regulation - drug effects Erythropoietin Erythropoietin - pharmacology Gene expression Growth factors Hospitals Hyperoxia Hypoxia Immunohistochemistry Injuries Ischemia Microscopy, Confocal Mitochondria - metabolism Myelin Basic Protein - metabolism Neuregulin-1 - genetics Neuregulin-1 - metabolism Neurodegeneration Neuronal Plasticity - drug effects Neurons Neuropilin-1 - genetics Neuropilin-1 - metabolism Neuroprotective Agents - pharmacology Oligodendroglia - cytology Oligodendroglia - drug effects Oligodendroglia - metabolism Premature birth Proteins Rats Rats, Wistar RNA Rodents Studies Synaptophysin - genetics Synaptophysin - metabolism Traumatic brain injury White Matter - drug effects White Matter - metabolism
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