Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions

Orally delivered small-molecule therapeutics are metabolized in the liver and intestine by phase I and phase II drug-metabolizing enzymes (DMEs), and transport proteins coordinate drug influx (phase 0) and drug/drug-metabolite efflux (phase III). Genes involved in drug metabolism and disposition are...

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Veröffentlicht in:	Nuclear Receptor Research 2015, Vol.2
Hauptverfasser:	Prakash, Chandra, Zuniga, Baltazar, Song, Chung Seog, Jiang, Shoulei, Cropper, Jodie, Park, Sulgi, Chatterjee, Bandana
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Analgesics Bile Birth defects Chemical compounds Cholesterol Conjugation Cytochrome Drug delivery systems Drugs Efflux Enzymes Epigenetics Functional groups Gene expression Genes Kinases Liver Metabolism Metabolites Methylation Nuclear reactions Organs Oxidation Pharmacology Phosphorylation Polymorphism Polypeptides Proteins Receptors Rodents Workflow
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